Detailed information of TA system TA241873

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1181953..1182680
• Replicon: chromosome
• Accession: NZ_CP095276
• Organism: Enterobacter hormaechei subsp. xiangfangensis strain HD8642

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: MU851_RS05530
• Protein ID: WP_045348581.1
• Coordinates: 1182369..1182680 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A8B3V464
• Locus tag: MU851_RS05525
• Protein ID: WP_022650546.1
• Coordinates: 1181953..1182372 (-)
• Length: 140 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (20-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (83-134)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12562.47 Da
• Isoelectric Point: 9.9435

>T241873 WP_045348581.1 NZ_CP095276:c1182680-1182369 [Enterobacter hormaechei subsp. xiangfangensis]
MHIVSRAPFDTAARHYPNQAQALDDLYRVLKKEHYPLPDEMRKRFPSLDRMKYREKWWVIDVGGGHLRVMFFADFERGKI
FIKHISTHADYDKLMDYYRRTKE

Nucleotide

• Length: 312 bp

>T241873 NZ_OU659121:146913-147191 [Providencia alcalifaciens]
ATGATAAAATCGTTTAAACATAAAGGGTTGAAACAACTCTTTGAAAAAGGAATAACTTCAGGGGTTCCGGCTCAAGATGC
TGAACGGATCAACGACCGTTTACAAGCAATAGATATCGCTAACGATATTCGTGAATTAGACCGCCAAATTTACAAATTGC
ATCCACTGAAAGGTGACAGAGAAGGTTATTGGTCAATAACAGTGCGAGCGAATTGGCGCATTACTTTTCAATTCATCAAT
GGTGATGCTTACATCTTAAATTATGAGGATTATCACTAA

Antitoxin

Protein

• Length: 140 a.a.
• Molecular weight: 15447.51 Da
• Isoelectric Point: 4.6051

>AT241873 WP_022650546.1 NZ_CP095276:c1182372-1181953 [Enterobacter hormaechei subsp. xiangfangensis]
MNYAAAIKAANALTNELPFLGSSPSRQDYEDALALVEYLIEHDPDNPLVEMLTAKIDKYENESPEFAEFNARIASIPSGV
ALLRTLMDQYQLTQSDFENEIGKKSLVSRILNGQRTLTLDHMRALAKRFGLPVSAFVGN

Nucleotide

• Length: 420 bp

>AT241873 NZ_OU659121:147191-147505 [Providencia alcalifaciens]
ATGAGACAGTTTAAAATATCTCACCCAGGTGAAATTATTGCACGAGATTTGGCTGATATGGGGATCAGTGGTCGACGTTT
TGCATTAAATATTGGTGTAACGCCAGCAACAGTTTCCCGTTTTTTATCAGGTAAAACAGCATTGACTCCCGCATTGGCAA
TCCGTATCGCCGCTGCACTAGGAAGTACTCCTGAATTTTGGTTACGTTTACAAAGTGCTTATGATTTACGTCAATTAGAA
AATCAAATTGATACGTCCGATATTATTTTGTATGAAGAGGCGCCTGATAGCGCTAAAGGCATATCCAAACATTAG

Structures

Antitoxin

• AlphaFold DB: A0A8B3V464