Detailed information of TA system TA241858

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4236651..4236909
• Replicon: chromosome
• Accession: NZ_CP095271
• Organism: Escherichia coli strain EC9682

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: MU524_RS20960
• Protein ID: WP_000809168.1
• Coordinates: 4236757..4236909 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4236651..4236708 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MU524_RS20945	4232483..4233742	-	1260	WP_000494924.1	hypothetical protein	-
MU524_RS20950	4233871..4235364	-	1494	WP_001350775.1	sulfatase-like hydrolase/transferase	-
MU524_RS20955	4235384..4236145	-	762	WP_001274823.1	outer membrane protein OmpK	-
-	4236651..4236708	-	58	-	-	Antitoxin
MU524_RS20960	4236757..4236909	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
MU524_RS20965	4237014..4238144	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
MU524_RS20970	4238233..4240149	-	1917	WP_000516135.1	molecular chaperone DnaK	-
MU524_RS20975	4240521..4240925	+	405	WP_000843687.1	DUF2541 family protein	-
MU524_RS20980	4240951..4241664	+	714	WP_001102393.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T241858 WP_000809168.1 NZ_CP095271:4236757-4236909 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T241858 NZ_OU659113:c2845996-2845586 [Providencia alcalifaciens]
GTGGTCCTGTGGAAATCTAATCTTTCCATTTCATGGAAAACCCAGCTTTTTTCAACCAGCCTCCATGTGGGGGCGGGTAT
CATTTTGCTTGTTGCACCATGGGAACCTGGTAACTCGATGATTTGGCTTCCATTATTGGTTATCTTAGTGGCGAGCTGGG
CAAAAAGTCAAAAGAACATTAGCAAAGTGAAAGGCGTTGCTGTACTGGTGAATGGCAATAAGCTTCAATGGAAAAAGAAT
GAGTGGGAAATAATCAAAGCACCATGGTGTAGCCGTTGTGGTATTTTATTGACGCTTAAGGCACTGCAAGGAAAGCCACA
GAAGCTGCGTTTGTGGGTGGCGAAAGATTCAGTGTCCGAAGAAAATTGGCGTAACCTCAATCAATTATTACTGCAATATC
CCGACATTTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT241858 NZ_CP095271:c4236708-4236651 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin