Detailed information of TA system TA241851

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hokW-rdlD/-
• Location: 2838659..2838884
• Replicon: chromosome
• Accession: NZ_CP095271
• Organism: Escherichia coli strain EC9682

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: A0A8S7B7V6
• Locus tag: MU524_RS13970
• Protein ID: WP_000813256.1
• Coordinates: 2838659..2838814 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	2838826..2838884 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MU524_RS13920	2833819..2833935	+	117	Protein_2736	hypothetical protein	-
MU524_RS13940	2834338..2835387	-	1050	WP_000935515.1	site-specific DNA-methyltransferase	-
MU524_RS13945	2835538..2835735	-	198	WP_000917749.1	hypothetical protein	-
MU524_RS13950	2835960..2836781	-	822	WP_000762880.1	antitermination protein	-
MU524_RS13955	2836778..2837152	-	375	WP_000904114.1	RusA family crossover junction endodeoxyribonuclease	-
MU524_RS13960	2837165..2838211	-	1047	WP_001265108.1	DUF968 domain-containing protein	-
MU524_RS13965	2838213..2838491	-	279	WP_011478175.1	hypothetical protein	-
MU524_RS13970	2838659..2838814	-	156	WP_000813256.1	type I toxin-antitoxin system toxin HokD	Toxin
-	2838826..2838884	+	59	-	-	Antitoxin
MU524_RS13975	2839432..2840433	-	1002	WP_000354966.1	hypothetical protein	-
MU524_RS13980	2840449..2841411	-	963	WP_014639476.1	hypothetical protein	-
MU524_RS13985	2841603..2842025	-	423	WP_001151216.1	DUF977 family protein	-
MU524_RS13990	2842066..2843136	-	1071	WP_001262357.1	hypothetical protein	-
MU524_RS13995	2843208..2843633	-	426	WP_000693867.1	toxin YdaT family protein	-
MU524_RS14000	2843617..2843859	-	243	WP_000747951.1	Cro/CI family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2803741..2854477	50736

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5764.94 Da
• Isoelectric Point: 6.1531

>T241851 WP_000813256.1 NZ_CP095271:c2838814-2838659 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTVYEPEE

Nucleotide

• Length: 156 bp

>T241851 NZ_OU453210:c4922633-4922349 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT241851 NZ_CP095271:2838826-2838884 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Antitoxin