Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 132675..132928 | Replicon | plasmid p21091025_1 |
| Accession | NZ_CP095265 | ||
| Organism | Klebsiella pneumoniae strain 21091025 | ||
Toxin (Protein)
| Gene name | srnB | Uniprot ID | G9G1E3 |
| Locus tag | MU321_RS27870 | Protein ID | WP_001312851.1 |
| Coordinates | 132779..132928 (+) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | srnC | ||
| Locus tag | - | ||
| Coordinates | 132675..132734 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MU321_RS27830 (128057) | 128057..128401 | - | 345 | Protein_162 | IS6-like element IS26 family transposase | - |
| MU321_RS27835 (128453) | 128453..129157 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| MU321_RS27840 (129182) | 129182..129382 | + | 201 | WP_072354025.1 | hypothetical protein | - |
| MU321_RS27845 (129402) | 129402..130148 | + | 747 | WP_000205770.1 | conjugal transfer pilus acetylase TraX | - |
| MU321_RS27850 (130203) | 130203..130763 | + | 561 | WP_000139328.1 | fertility inhibition protein FinO | - |
| MU321_RS27855 (130895) | 130895..131095 | + | 201 | WP_015059022.1 | hypothetical protein | - |
| MU321_RS27860 (131481) | 131481..132080 | + | 600 | WP_032083981.1 | PIN domain-containing protein | - |
| MU321_RS27865 (132142) | 132142..132474 | + | 333 | WP_152916585.1 | hypothetical protein | - |
| - (132675) | 132675..132734 | - | 60 | NuclAT_1 | - | Antitoxin |
| - (132675) | 132675..132734 | - | 60 | NuclAT_1 | - | Antitoxin |
| - (132675) | 132675..132734 | - | 60 | NuclAT_1 | - | Antitoxin |
| - (132675) | 132675..132734 | - | 60 | NuclAT_1 | - | Antitoxin |
| MU321_RS27870 (132779) | 132779..132928 | + | 150 | WP_001312851.1 | Hok/Gef family protein | Toxin |
| MU321_RS27875 (133212) | 133212..133460 | + | 249 | WP_000083837.1 | replication regulatory protein RepA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | blaCTX-M-65 / blaTEM-1B / rmtB / blaSHV-12 / blaKPC-2 | - | 1..133771 | 133771 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5542.67 Da Isoelectric Point: 8.7678
>T241830 WP_001312851.1 NZ_CP095265:132779-132928 [Klebsiella pneumoniae]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
>T241830 NZ_OU342919:3575423-3575677 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTTTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTTTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Antitoxin
Download Length: 60 bp
>AT241830 NZ_CP095265:c132734-132675 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
