Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 35049..35318 Replicon plasmid p21091025_1
Accession NZ_CP095265
Organism Klebsiella pneumoniae strain 21091025

Toxin (Protein)


Gene name hok Uniprot ID -
Locus tag MU321_RS27255 Protein ID WP_001372321.1
Coordinates 35193..35318 (+) Length 42 a.a.

Antitoxin (RNA)


Gene name sok
Locus tag -
Coordinates 35049..35114 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU321_RS27225 30759..31286 + 528 WP_000290834.1 single-stranded DNA-binding protein -
MU321_RS27230 31344..31577 + 234 WP_000006003.1 DUF905 family protein -
MU321_RS27235 31638..33661 + 2024 Protein_43 ParB/RepB/Spo0J family partition protein -
MU321_RS27240 33730..34164 + 435 WP_000845953.1 conjugation system SOS inhibitor PsiB -
MU321_RS27245 34161..34880 + 720 WP_001276217.1 plasmid SOS inhibition protein A -
- 34892..35116 + 225 NuclAT_0 - -
- 34892..35116 + 225 NuclAT_0 - -
- 34892..35116 + 225 NuclAT_0 - -
- 34892..35116 + 225 NuclAT_0 - -
- 35049..35114 - 66 - - Antitoxin
MU321_RS27250 35102..35251 + 150 Protein_46 plasmid maintenance protein Mok -
MU321_RS27255 35193..35318 + 126 WP_001372321.1 type I toxin-antitoxin system Hok family toxin Toxin
MU321_RS27260 35637..35933 - 297 Protein_48 hypothetical protein -
MU321_RS27265 36233..36529 + 297 WP_001272251.1 hypothetical protein -
MU321_RS27270 36640..37461 + 822 WP_001234445.1 DUF932 domain-containing protein -
MU321_RS27275 37758..38405 - 648 WP_015059008.1 transglycosylase SLT domain-containing protein -
MU321_RS27280 38682..39065 + 384 WP_000124981.1 conjugal transfer relaxosome DNA-binding protein TraM -
MU321_RS27285 39346..40050 + 705 WP_001067855.1 IS6-like element IS26 family transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid blaCTX-M-65 / blaTEM-1B / rmtB / blaSHV-12 / blaKPC-2 - 1..133771 133771


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-37)


Sequences


Toxin        


Download         Length: 42 a.a.        Molecular weight: 4780.69 Da        Isoelectric Point: 8.5110

>T241827 WP_001372321.1 NZ_CP095265:35193-35318 [Klebsiella pneumoniae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Download         Length: 126 bp

>T241827 NZ_OU342919:2699170-2699505 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 66 bp

>AT241827 NZ_CP095265:c35114-35049 [Klebsiella pneumoniae]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References