Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 1828..2081 Replicon plasmid p21080937_10
Accession NZ_CP095263
Organism Klebsiella pneumoniae strain 21080937

Toxin (Protein)


Gene name srnB Uniprot ID G9G1E3
Locus tag MU320_RS29285 Protein ID WP_001312851.1
Coordinates 1828..1977 (-) Length 50 a.a.

Antitoxin (RNA)


Gene name srnC
Locus tag -
Coordinates 2022..2081 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU320_RS29265 (127) 127..984 - 858 WP_032495102.1 incFII family plasmid replication initiator RepA -
MU320_RS29395 (977) 977..1051 - 75 WP_001375168.1 RepA leader peptide Tap -
MU320_RS29280 (1296) 1296..1544 - 249 WP_000083837.1 replication regulatory protein RepA -
MU320_RS29285 (1828) 1828..1977 - 150 WP_001312851.1 Hok/Gef family protein Toxin
- (2022) 2022..2081 + 60 NuclAT_0 - Antitoxin
- (2022) 2022..2081 + 60 NuclAT_0 - Antitoxin
- (2022) 2022..2081 + 60 NuclAT_0 - Antitoxin
- (2022) 2022..2081 + 60 NuclAT_0 - Antitoxin
MU320_RS29290 (2282) 2282..2614 - 333 WP_152916585.1 hypothetical protein -
MU320_RS29295 (2676) 2676..3275 - 600 WP_032083981.1 PIN domain-containing protein -
MU320_RS29300 (3661) 3661..3861 - 201 WP_015059022.1 hypothetical protein -
MU320_RS29305 (3993) 3993..4553 - 561 WP_000139328.1 fertility inhibition protein FinO -
MU320_RS29310 (4608) 4608..5354 - 747 WP_000205770.1 conjugal transfer pilus acetylase TraX -
MU320_RS29315 (5374) 5374..5535 - 162 Protein_9 protein traI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..5535 5535


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(4-45)


Sequences

Toxin        


Download         Length: 50 a.a.        Molecular weight: 5542.67 Da        Isoelectric Point: 8.7678

>T241805 WP_001312851.1 NZ_CP095263:c1977-1828 [Klebsiella pneumoniae]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK

Download         Length: 150 bp

>T241805 NZ_OU342706:1635429-1635531 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 60 bp

>AT241805 NZ_CP095263:2022-2081 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C8K5

Antitoxin

Download structure file

References