Detailed information of TA system TA241802

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 40594..41020
• Replicon: plasmid p21080937_3
• Accession: NZ_CP095256
• Organism: Klebsiella pneumoniae strain 21080937

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: MU320_RS28335
• Protein ID: WP_001372321.1
• Coordinates: 40594..40719 (-)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	40796..41020 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MU320_RS28295 (35632)	35632..35859	-	228	WP_001254388.1	conjugal transfer relaxosome protein TraY	-
MU320_RS28300 (35953)	35953..36639	-	687	WP_000332487.1	PAS domain-containing protein	-
MU320_RS28305 (36833)	36833..37216	-	384	WP_001151564.1	conjugal transfer relaxosome DNA-binding protein TraM	-
MU320_RS28310 (37511)	37511..38149	+	639	WP_281440555.1	transglycosylase SLT domain-containing protein	-
MU320_RS28315 (38446)	38446..39267	-	822	WP_001234469.1	DUF932 domain-containing protein	-
MU320_RS28320 (39388)	39388..39675	-	288	WP_000107537.1	hypothetical protein	-
MU320_RS28325 (39973)	39973..40146	+	174	Protein_49	hypothetical protein	-
MU320_RS28330 (40144)	40144..40374	-	231	WP_071587244.1	hypothetical protein	-
MU320_RS28335 (40594)	40594..40719	-	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
MU320_RS28340 (40661)	40661..40810	-	150	Protein_52	plasmid maintenance protein Mok	-
- (40796)	40796..41020	-	225	NuclAT_0	-	Antitoxin
- (40796)	40796..41020	-	225	NuclAT_0	-	Antitoxin
- (40796)	40796..41020	-	225	NuclAT_0	-	Antitoxin
- (40796)	40796..41020	-	225	NuclAT_0	-	Antitoxin
MU320_RS28345 (40989)	40989..41751	-	763	Protein_53	plasmid SOS inhibition protein A	-
MU320_RS28350 (41748)	41748..42182	-	435	WP_000845901.1	conjugation system SOS inhibitor PsiB	-
MU320_RS28355 (42237)	42237..44195	-	1959	WP_032152921.1	ParB/RepB/Spo0J family partition protein	-
MU320_RS28360 (44254)	44254..44487	-	234	WP_000006018.1	DUF905 domain-containing protein	-
MU320_RS28365 (44543)	44543..45070	-	528	WP_000290793.1	single-stranded DNA-binding protein	-
MU320_RS28370 (45540)	45540..45788	-	249	WP_071606928.1	hypothetical protein	-
MU320_RS28375 (45710)	45710..45940	-	231	WP_001333093.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	aac(3)-IId	-	1..68628	68628

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T241802 WP_001372321.1 NZ_CP095256:c40719-40594 [Klebsiella pneumoniae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T241802 NZ_OU342706:34628-34996 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGTCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTATAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin

Nucleotide

• Length: 225 bp

>AT241802 NZ_CP095256:c41020-40796 [Klebsiella pneumoniae]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Structures

Antitoxin