Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 128805..129058 | Replicon | plasmid p21080534_1 |
| Accession | NZ_CP095248 | ||
| Organism | Klebsiella pneumoniae strain 21080534 | ||
Toxin (Protein)
| Gene name | srnB | Uniprot ID | G9G1E3 |
| Locus tag | MU311_RS27620 | Protein ID | WP_001312851.1 |
| Coordinates | 128805..128954 (-) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | srnC | ||
| Locus tag | - | ||
| Coordinates | 128999..129058 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MU311_RS27580 (124164) | 124164..124579 | - | 416 | Protein_149 | IS1-like element IS1B family transposase | - |
| MU311_RS27585 (124828) | 124828..125229 | - | 402 | WP_001398199.1 | type II toxin-antitoxin system toxin endoribonuclease PemK | - |
| MU311_RS27590 (125162) | 125162..125419 | - | 258 | WP_000557619.1 | type II toxin-antitoxin system antitoxin PemI | - |
| MU311_RS27595 (125512) | 125512..126165 | - | 654 | WP_000616807.1 | CPBP family intramembrane metalloprotease | - |
| MU311_RS27600 (127104) | 127104..127961 | - | 858 | WP_032495102.1 | incFII family plasmid replication initiator RepA | - |
| MU311_RS28930 (127954) | 127954..128028 | - | 75 | WP_001375168.1 | RepA leader peptide Tap | - |
| MU311_RS27615 (128273) | 128273..128521 | - | 249 | WP_000083837.1 | replication regulatory protein RepA | - |
| MU311_RS27620 (128805) | 128805..128954 | - | 150 | WP_001312851.1 | Hok/Gef family protein | Toxin |
| - (128999) | 128999..129058 | + | 60 | NuclAT_1 | - | Antitoxin |
| - (128999) | 128999..129058 | + | 60 | NuclAT_1 | - | Antitoxin |
| - (128999) | 128999..129058 | + | 60 | NuclAT_1 | - | Antitoxin |
| - (128999) | 128999..129058 | + | 60 | NuclAT_1 | - | Antitoxin |
| MU311_RS27625 (129259) | 129259..129591 | - | 333 | WP_152916585.1 | hypothetical protein | - |
| MU311_RS27630 (129653) | 129653..130252 | - | 600 | WP_032083981.1 | PIN domain-containing protein | - |
| MU311_RS27635 (130638) | 130638..130838 | - | 201 | WP_015059022.1 | hypothetical protein | - |
| MU311_RS27640 (130970) | 130970..131530 | - | 561 | WP_000139328.1 | fertility inhibition protein FinO | - |
| MU311_RS27645 (131585) | 131585..132331 | - | 747 | WP_000205770.1 | conjugal transfer pilus acetylase TraX | - |
| MU311_RS27650 (132351) | 132351..132551 | - | 201 | WP_072354025.1 | hypothetical protein | - |
| MU311_RS27655 (132576) | 132576..133280 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| MU311_RS27660 (133332) | 133332..133676 | + | 345 | Protein_164 | IS6-like element IS26 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaKPC-2 / blaSHV-12 | rmpA2 / iutA / iucD / iucC / iucB / iucA / iucA | 1..210914 | 210914 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5542.67 Da Isoelectric Point: 8.7678
>T241775 WP_001312851.1 NZ_CP095248:c128954-128805 [Klebsiella pneumoniae]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
>T241775 NZ_OU015348:2269-3132 [Enterococcus faecium]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAGAATCGCTTAAATGATAATTTAGAAGAATTGATTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTT
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGTG
AAACTTTATGAAAAAGACGTAGTAAAACACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
CGATCAAGGGTATAATTTGGTGATCGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTCATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGATATGAA
ACCATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTATATAACAGAGAAGGAGTAAAACTCTATTCAA
GTTTGGAAACACCTTCTATTAGTCCAAAAGAAACCTTAGAAAAAGAATTGAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTAGAACGAATAGAGCAAAAAATGGTTCTAAATAAACACCAAGAGACACCTGAATTTAAAGCAATTCAACAAAA
ATTGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGTATTTAA
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAGAATCGCTTAAATGATAATTTAGAAGAATTGATTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTT
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGTG
AAACTTTATGAAAAAGACGTAGTAAAACACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
CGATCAAGGGTATAATTTGGTGATCGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTCATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGATATGAA
ACCATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTATATAACAGAGAAGGAGTAAAACTCTATTCAA
GTTTGGAAACACCTTCTATTAGTCCAAAAGAAACCTTAGAAAAAGAATTGAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTAGAACGAATAGAGCAAAAAATGGTTCTAAATAAACACCAAGAGACACCTGAATTTAAAGCAATTCAACAAAA
ATTGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGTATTTAA
Antitoxin
Download Length: 60 bp
>AT241775 NZ_CP095248:128999-129058 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
