Detailed information of TA system TA241747

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 30927..31196
• Replicon: plasmid p21080237_2
• Accession: NZ_CP095242
• Organism: Klebsiella pneumoniae strain 21080237

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: MU300_RS27745
• Protein ID: WP_001372321.1
• Coordinates: 31071..31196 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	30927..30992 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MU300_RS27715	26637..27164	+	528	WP_000290834.1	single-stranded DNA-binding protein	-
MU300_RS27720	27222..27455	+	234	WP_000006003.1	DUF905 family protein	-
MU300_RS27725	27516..29539	+	2024	Protein_38	ParB/RepB/Spo0J family partition protein	-
MU300_RS27730	29608..30042	+	435	WP_000845953.1	conjugation system SOS inhibitor PsiB	-
MU300_RS27735	30039..30758	+	720	WP_001276217.1	plasmid SOS inhibition protein A	-
-	30770..30994	+	225	NuclAT_0	-	-
-	30770..30994	+	225	NuclAT_0	-	-
-	30770..30994	+	225	NuclAT_0	-	-
-	30770..30994	+	225	NuclAT_0	-	-
-	30927..30992	-	66	-	-	Antitoxin
MU300_RS27740	30980..31129	+	150	Protein_41	plasmid maintenance protein Mok	-
MU300_RS27745	31071..31196	+	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
MU300_RS27750	31515..31811	-	297	Protein_43	hypothetical protein	-
MU300_RS27755	32111..32407	+	297	WP_001272251.1	hypothetical protein	-
MU300_RS27760	32518..33339	+	822	WP_001234445.1	DUF932 domain-containing protein	-
MU300_RS27765	33636..34283	-	648	WP_015059008.1	transglycosylase SLT domain-containing protein	-
MU300_RS27770	34560..34943	+	384	WP_000124981.1	conjugal transfer relaxosome DNA-binding protein TraM	-
MU300_RS27775	35224..35928	+	705	WP_001067855.1	IS6-like element IS26 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	blaTEM-1B / rmtB / blaSHV-12 / blaKPC-2	-	1..129649	129649

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T241747 WP_001372321.1 NZ_CP095242:31071-31196 [Klebsiella pneumoniae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T241747 NZ_OU015340:c3075017-3074706 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Nucleotide

• Length: 66 bp

>AT241747 NZ_CP095242:c30992-30927 [Klebsiella pneumoniae]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT

Structures

Antitoxin