Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 57876..58129 Replicon plasmid p21072329_2
Accession NZ_CP095236
Organism Klebsiella pneumoniae strain 21072329

Toxin (Protein)


Gene name srnB Uniprot ID G9G1E3
Locus tag MU289_RS28420 Protein ID WP_001312851.1
Coordinates 57980..58129 (+) Length 50 a.a.

Antitoxin (RNA)


Gene name srnC
Locus tag -
Coordinates 57876..57935 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU289_RS28385 (53654) 53654..54358 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
MU289_RS28390 (54383) 54383..54583 + 201 WP_072354025.1 hypothetical protein -
MU289_RS28395 (54603) 54603..55349 + 747 WP_000205770.1 conjugal transfer pilus acetylase TraX -
MU289_RS28400 (55404) 55404..55964 + 561 WP_000139328.1 fertility inhibition protein FinO -
MU289_RS28405 (56096) 56096..56296 + 201 WP_015059022.1 hypothetical protein -
MU289_RS28410 (56682) 56682..57281 + 600 WP_032083981.1 PIN domain-containing protein -
MU289_RS28415 (57343) 57343..57675 + 333 WP_152916585.1 hypothetical protein -
- (57876) 57876..57935 - 60 NuclAT_0 - Antitoxin
- (57876) 57876..57935 - 60 NuclAT_0 - Antitoxin
- (57876) 57876..57935 - 60 NuclAT_0 - Antitoxin
- (57876) 57876..57935 - 60 NuclAT_0 - Antitoxin
MU289_RS28420 (57980) 57980..58129 + 150 WP_001312851.1 Hok/Gef family protein Toxin
MU289_RS28425 (58413) 58413..58661 + 249 WP_000083837.1 replication regulatory protein RepA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aac(3)-IId - 1..58972 58972


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(4-45)


Sequences

Toxin        


Download         Length: 50 a.a.        Molecular weight: 5542.67 Da        Isoelectric Point: 8.7678

>T241723 WP_001312851.1 NZ_CP095236:57980-58129 [Klebsiella pneumoniae]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK

Download         Length: 150 bp

>T241723 NZ_OD940440:2718266-2718409 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTAAAAGAAAACAATAAAAAATAA

Antitoxin


Download         Length: 60 bp

>AT241723 NZ_CP095236:c57935-57876 [Klebsiella pneumoniae]
TAAGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C8K5

Antitoxin

Download structure file

References