Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1988852..1989371 Replicon chromosome
Accession NZ_CP095162
Organism Streptococcus suis strain TJS75

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0Z8M4E9
Locus tag MUY23_RS09640 Protein ID WP_002939009.1
Coordinates 1988852..1989109 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag MUY23_RS09645 Protein ID WP_002939010.1
Coordinates 1989111..1989371 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUY23_RS09625 1985483..1987213 - 1731 WP_024390921.1 membrane protein -
MUY23_RS09630 1987416..1988288 - 873 WP_002939007.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
MUY23_RS09635 1988308..1988838 - 531 WP_002939008.1 DUF1697 domain-containing protein -
MUY23_RS09640 1988852..1989109 - 258 WP_002939009.1 Txe/YoeB family addiction module toxin Toxin
MUY23_RS09645 1989111..1989371 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUY23_RS09650 1989447..1989902 - 456 WP_002939012.1 8-oxo-dGTP diphosphatase -
MUY23_RS09655 1989906..1990274 - 369 WP_002939013.1 hypothetical protein -
MUY23_RS09660 1990267..1990836 - 570 WP_014637213.1 ribonuclease M5 -
MUY23_RS09665 1990820..1991602 - 783 WP_002939015.1 TatD family hydrolase -
MUY23_RS09670 1991711..1991848 - 138 WP_002939016.1 50S ribosomal protein L34 -
MUY23_RS09675 1992016..1993011 - 996 WP_013730624.1 RNA-binding cell elongation regulator Jag/EloR -
MUY23_RS09680 1993031..1993843 - 813 WP_004194552.1 YidC/Oxa1 family membrane protein insertase -
MUY23_RS09685 1993827..1994186 - 360 WP_004194560.1 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10321.83 Da        Isoelectric Point: 7.3119

>T241614 WP_002939009.1 NZ_CP095162:c1989109-1988852 [Streptococcus suis]
MGIHFTEDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEVDKLYILSL
KDHYG

Download         Length: 258 bp

>T241614 NZ_LT992493:c279553-279056 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT241614 WP_002939010.1 NZ_CP095162:c1989371-1989111 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp

>AT241614 NZ_LT992493:c279822-279550 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8M4E9

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References