Detailed information of TA system TA241603

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 866146..866730
• Replicon: chromosome
• Accession: NZ_CP095161
• Organism: Avibacterium paragallinarum strain ZJ-C

Toxin (Protein)

• Gene name: graT
• Uniprot ID: -
• Locus tag: LNL76_RS04195
• Protein ID: WP_110478986.1
• Coordinates: 866146..866424 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LNL76_RS04200
• Protein ID: WP_110478985.1
• Coordinates: 866434..866730 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LNL76_RS04180	861995..863077	-	1083	WP_110478989.1	peptide chain release factor 1	-
LNL76_RS04185	863281..864570	-	1290	WP_110478988.1	serine--tRNA ligase	-
LNL76_RS04190	864644..865993	-	1350	WP_110478987.1	replication-associated recombination protein A	-
LNL76_RS04195	866146..866424	+	279	WP_110478986.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LNL76_RS04200	866434..866730	+	297	WP_110478985.1	HigA family addiction module antitoxin	Antitoxin
LNL76_RS04205	866782..867402	-	621	WP_194742997.1	outer membrane lipoprotein chaperone LolA	-
LNL76_RS04210	867484..870336	-	2853	WP_110478983.1	DNA translocase FtsK 4TM domain-containing protein	-
LNL76_RS04215	870338..870817	-	480	WP_110478982.1	leucine-responsive transcriptional regulator Lrp	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (1-92)

Antitoxin

• Cro/C1-type helix-turn-helix domain (15-67)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10852.50 Da
• Isoelectric Point: 8.5384

>T241603 WP_110478986.1 NZ_CP095161:866146-866424 [Avibacterium paragallinarum]
MITHFTCKDTQAFFEGQRIRRFIPFEKVAMRKLQQLNAATELDFLRIPPGNHLEMLTGDRKGQYSIRINDQWRICFTWLN
GHAADVAIVDYH

Nucleotide

• Length: 279 bp

>T241603 NZ_LT992493:c214725-214408 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11127.72 Da
• Isoelectric Point: 7.3167

>AT241603 WP_110478985.1 NZ_CP095161:866434-866730 [Avibacterium paragallinarum]
MTRQIPLSHPGEILLEEWLKPLGISQYALAKAISVPPRRINEIVKGKRAITPDTALRLATYFGTDPQSWLNLQSHYDTEQ
TRTAINEDLTHISPFQFA

Nucleotide

• Length: 297 bp

>AT241603 NZ_LT992493:c214986-214744 [Vibrio cholerae]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA