Detailed information of TA system TA241599

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 113384..114019
• Replicon: chromosome
• Accession: NZ_CP095161
• Organism: Avibacterium paragallinarum strain ZJ-C

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0F5EY10
• Locus tag: LNL76_RS00530
• Protein ID: WP_017806021.1
• Coordinates: 113384..113689 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: LNL76_RS00535
• Protein ID: WP_046098498.1
• Coordinates: 113699..114019 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LNL76_RS00510	108556..109815	-	1260	WP_110478584.1	glutamate-5-semialdehyde dehydrogenase	-
LNL76_RS00515	109824..110495	-	672	WP_046097465.1	trimeric intracellular cation channel family protein	-
LNL76_RS00520	110658..111479	+	822	Protein_105	hypothetical protein	-
LNL76_RS00525	111917..113272	+	1356	WP_194742916.1	outer membrane protein transport protein	-
LNL76_RS00530	113384..113689	+	306	WP_017806021.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LNL76_RS00535	113699..114019	+	321	WP_046098498.1	HigA family addiction module antitoxin	Antitoxin
LNL76_RS00540	114066..114636	+	571	Protein_109	methylated-DNA--[protein]-cysteine S-methyltransferase	-
LNL76_RS00545	114629..115297	+	669	WP_017806018.1	DNA mismatch repair endonuclease MutH	-
LNL76_RS00550	115437..116159	+	723	WP_017806017.1	TerC family protein	-
LNL76_RS00555	116315..116848	-	534	WP_017806016.1	disulfide bond formation protein DsbB	-
LNL76_RS00560	116861..118402	-	1542	WP_017806015.1	Na(+)/H(+) antiporter NhaB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (5-99)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (6-84)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 12192.01 Da
• Isoelectric Point: 9.5601

>T241599 WP_017806021.1 NZ_CP095161:113384-113689 [Avibacterium paragallinarum]
MFNLTAKHFKDDYLYRFFQYGELHSKIPMTLSKVLARKLDMINAAENLNDLRSPPANRLELLEPKENKRYSIRVNKQYRL
IFHFDNGELSQLYLDPHRYDL

Nucleotide

• Length: 306 bp

>T241599 NZ_LT992491:c956219-955950 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGCCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTGCCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12055.83 Da
• Isoelectric Point: 6.8792

>AT241599 WP_046098498.1 NZ_CP095161:113699-114019 [Avibacterium paragallinarum]
MFPTQRKPTSVGEILQEEFLLPLNLKINDLAEILDVHRNTASNLVSNHSKVTLEMAVKLAKAFGTSPEFWINLQNAVDLW
ELNHNDRFQQSLSKVKIAHYPPAFSV

Nucleotide

• Length: 321 bp

>AT241599 NZ_LT992491:c955956-955435 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAATGCACCTTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CTTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Structures

Toxin

• AlphaFold DB: A0A0F5EY10