Detailed information of TA system TA241582

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-rdlD/SymE(toxin)
• Location: 4214558..4214970
• Replicon: chromosome
• Accession: NZ_CP095155
• Organism: Escherichia coli strain Iso00041

Toxin (Protein)

• Gene name: symE
• Uniprot ID: U9YSY7
• Locus tag: MU410_RS20360
• Protein ID: WP_000132601.1
• Coordinates: 4214629..4214970 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	4214558..4214634 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MU410_RS20350 (4211421)	4211421..4213010	+	1590	WP_001063200.1	type I restriction-modification system methyltransferase	-
MU410_RS20355 (4213007)	4213007..4214401	+	1395	WP_001272445.1	type I restriction-modification system specificity subunit	-
- (4214558)	4214558..4214634	-	77	NuclAT_14	-	Antitoxin
- (4214558)	4214558..4214634	-	77	NuclAT_14	-	Antitoxin
- (4214558)	4214558..4214634	-	77	NuclAT_14	-	Antitoxin
- (4214558)	4214558..4214634	-	77	NuclAT_14	-	Antitoxin
- (4214558)	4214558..4214634	-	77	NuclAT_15	-	Antitoxin
- (4214558)	4214558..4214634	-	77	NuclAT_15	-	Antitoxin
- (4214558)	4214558..4214634	-	77	NuclAT_15	-	Antitoxin
- (4214558)	4214558..4214634	-	77	NuclAT_15	-	Antitoxin
MU410_RS20360 (4214629)	4214629..4214970	+	342	WP_000132601.1	endoribonuclease SymE	Toxin
MU410_RS20365 (4215132)	4215132..4216511	+	1380	WP_000443951.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
MU410_RS20370 (4216511)	4216511..4217557	+	1047	WP_000437621.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12203.02 Da
• Isoelectric Point: 8.5012

>T241582 WP_000132601.1 NZ_CP095155:4214629-4214970 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T241582 NZ_LT992489:454248-454745 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin

Nucleotide

• Length: 77 bp

>AT241582 NZ_CP095155:c4214634-4214558 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: U9YSY7

Antitoxin