Detailed information of TA system TA241563

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 764943..765636
• Replicon: chromosome
• Accession: NZ_CP095155
• Organism: Escherichia coli strain Iso00041

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: S1EZG2
• Locus tag: MU410_RS03750
• Protein ID: WP_000415584.1
• Coordinates: 764943..765239 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: S1EBV2
• Locus tag: MU410_RS03755
• Protein ID: WP_000650107.1
• Coordinates: 765241..765636 (+)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MU410_RS03715 (760031)	760031..760345	-	315	WP_000958598.1	putative quinol monooxygenase	-
MU410_RS03720 (760376)	760376..760957	-	582	WP_000065430.1	NADPH:quinone oxidoreductase MdaB	-
MU410_RS03725 (761276)	761276..761608	+	333	WP_023149630.1	DUF2645 family protein	-
MU410_RS03730 (761654)	761654..763003	-	1350	WP_001401139.1	quorum sensing histidine kinase QseC	-
MU410_RS03735 (763000)	763000..763659	-	660	WP_001221493.1	quorum sensing response regulator transcription factor QseB	-
MU410_RS03740 (763811)	763811..764203	+	393	WP_000712658.1	OB fold stress tolerance protein YgiW	-
MU410_RS03745 (764256)	764256..764738	+	483	WP_000183505.1	GyrI-like domain-containing protein	-
MU410_RS03750 (764943)	764943..765239	+	297	WP_000415584.1	type II toxin-antitoxin system toxin MqsR	Toxin
MU410_RS03755 (765241)	765241..765636	+	396	WP_000650107.1	type II toxin-antitoxin system antitoxin MqsA	Antitoxin
MU410_RS03760 (765769)	765769..767376	+	1608	WP_001295629.1	ABC transporter substrate-binding protein	-
MU410_RS03765 (767514)	767514..769772	+	2259	WP_001281841.1	DNA topoisomerase IV subunit A	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Zinc finger, MqsA-type (3-47)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11231.96 Da
• Isoelectric Point: 8.9070

>T241563 WP_000415584.1 NZ_CP095155:764943-765239 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Nucleotide

• Length: 297 bp

>T241563 NZ_LT992487:972448-972945 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14703.10 Da
• Isoelectric Point: 9.2136

>AT241563 WP_000650107.1 NZ_CP095155:765241-765636 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Nucleotide

• Length: 396 bp

>AT241563 NZ_LT992487:972179-972451 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Structures

Toxin

• PDB: 3HI2

Antitoxin

• PDB: 3HI2
• PDB: 3GA8
• PDB: 3O9X
• PDB: 2KZ8
• PDB: 3FMY
• PDB: 3GN5
• AlphaFold DB: A0A7U9LU65