Detailed information of TA system TA241559

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 41235..41504
• Replicon: plasmid pIso00073_03
• Accession: NZ_CP095153
• Organism: Klebsiella pneumoniae strain Iso00073

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: MU411_RS28210
• Protein ID: WP_001372321.1
• Coordinates: 41379..41504 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	41235..41300 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MU411_RS28180	36945..37472	+	528	WP_000290834.1	single-stranded DNA-binding protein	-
MU411_RS28185	37530..37763	+	234	WP_000006003.1	DUF905 family protein	-
MU411_RS28190	37824..39847	+	2024	Protein_44	ParB/RepB/Spo0J family partition protein	-
MU411_RS28195	39916..40350	+	435	WP_000845953.1	conjugation system SOS inhibitor PsiB	-
MU411_RS28200	40347..41066	+	720	WP_001276217.1	plasmid SOS inhibition protein A	-
-	41078..41302	+	225	NuclAT_0	-	-
-	41078..41302	+	225	NuclAT_0	-	-
-	41078..41302	+	225	NuclAT_0	-	-
-	41078..41302	+	225	NuclAT_0	-	-
-	41235..41300	-	66	-	-	Antitoxin
MU411_RS28205	41288..41437	+	150	Protein_47	plasmid maintenance protein Mok	-
MU411_RS28210	41379..41504	+	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
MU411_RS28215	41823..42119	-	297	Protein_49	hypothetical protein	-
MU411_RS28220	42419..42715	+	297	WP_001272251.1	hypothetical protein	-
MU411_RS28225	42826..43647	+	822	WP_001234445.1	DUF932 domain-containing protein	-
MU411_RS28230	43944..44534	-	591	WP_000252683.1	transglycosylase SLT domain-containing protein	-
MU411_RS28235	44869..45252	+	384	WP_001354030.1	conjugal transfer relaxosome DNA-binding protein TraM	-
MU411_RS28240	45446..46117	+	672	WP_000283561.1	conjugal transfer transcriptional regulator TraJ	-
MU411_RS28245	46254..46481	+	228	WP_000089263.1	conjugal transfer relaxosome protein TraY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T241559 WP_001372321.1 NZ_CP095153:41379-41504 [Klebsiella pneumoniae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T241559 NZ_LT992487:943097-943414 [Vibrio cholerae]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG

Antitoxin

Nucleotide

• Length: 66 bp

>AT241559 NZ_CP095153:c41300-41235 [Klebsiella pneumoniae]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT

Structures

Antitoxin