Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 352116..352762 Replicon chromosome
Accession NZ_CP095145
Organism Klebsiella pneumoniae strain Iso00100

Toxin (Protein)


Gene name higB Uniprot ID A0A486UPU4
Locus tag MU412_RS01625 Protein ID WP_032417639.1
Coordinates 352116..352463 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag MU412_RS01630 Protein ID WP_002920557.1
Coordinates 352463..352762 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU412_RS01615 (348042) 348042..349475 + 1434 WP_002920564.1 glycogen synthase GlgA -
MU412_RS01620 (349493) 349493..351940 + 2448 WP_002920561.1 glycogen phosphorylase -
MU412_RS01625 (352116) 352116..352463 + 348 WP_032417639.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MU412_RS01630 (352463) 352463..352762 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
MU412_RS01635 (352825) 352825..354333 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
MU412_RS01640 (354538) 354538..354867 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
MU412_RS01645 (354918) 354918..355748 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
MU412_RS01650 (355798) 355798..356556 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13527.52 Da        Isoelectric Point: 5.6802

>T241520 WP_032417639.1 NZ_CP095145:352116-352463 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATILILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFEPLRKAI
VLCAGDKDGMNEKRFYKELITLADREFSQHLTKER

Download         Length: 348 bp

>T241520 NZ_LT992475:474545-474697 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT241520 WP_002920557.1 NZ_CP095145:352463-352762 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT241520 NZ_LT992475:473921-474520 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATGTAG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAACAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTTGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
CGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486UPU4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References