Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | HipBST/HipA(toxin) |
| Location | 232191..233509 | Replicon | chromosome |
| Accession | NZ_CP095137 | ||
| Organism | Escherichia coli strain Iso00225 | ||
Toxin (Protein)
| Gene name | HipT | Uniprot ID | F4T5A3 |
| Locus tag | MU414_RS01130 | Protein ID | WP_001262467.1 |
| Coordinates | 232502..233509 (+) | Length | 336 a.a. |
Antitoxin (Protein)
| Gene name | HipS | Uniprot ID | F4T5A4 |
| Locus tag | MU414_RS01125 | Protein ID | WP_001312177.1 |
| Coordinates | 232191..232502 (+) | Length | 104 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MU414_RS01100 (227723) | 227723..228742 | + | 1020 | WP_000938855.1 | dipeptide ABC transporter permease DppB | - |
| MU414_RS01105 (228752) | 228752..229654 | + | 903 | WP_000084677.1 | dipeptide ABC transporter permease DppC | - |
| MU414_RS01110 (229665) | 229665..230648 | + | 984 | WP_001196477.1 | dipeptide ABC transporter ATP-binding protein | - |
| MU414_RS01115 (230645) | 230645..231658 | + | 1014 | WP_000103572.1 | dipeptide ABC transporter ATP-binding subunit DppF | - |
| MU414_RS01120 (231883) | 231883..232206 | + | 324 | WP_000563102.1 | helix-turn-helix transcriptional regulator | - |
| MU414_RS01125 (232191) | 232191..232502 | + | 312 | WP_001312177.1 | HipA N-terminal domain-containing protein | Antitoxin |
| MU414_RS01130 (232502) | 232502..233509 | + | 1008 | WP_001262467.1 | HipA domain-containing protein | Toxin |
| MU414_RS01135 (233526) | 233526..234797 | - | 1272 | WP_001545666.1 | amino acid permease | - |
| - (235159) | 235159..235224 | - | 66 | NuclAT_27 | - | - |
| - (235159) | 235159..235224 | - | 66 | NuclAT_27 | - | - |
| - (235159) | 235159..235224 | - | 66 | NuclAT_27 | - | - |
| - (235159) | 235159..235224 | - | 66 | NuclAT_27 | - | - |
| MU414_RS01140 (235273) | 235273..235380 | + | 108 | WP_001295224.1 | type I toxin-antitoxin system toxin Ldr family protein | - |
| - (235642) | 235642..235699 | - | 58 | NuclAT_26 | - | - |
| - (235642) | 235642..235699 | - | 58 | NuclAT_26 | - | - |
| - (235642) | 235642..235699 | - | 58 | NuclAT_26 | - | - |
| - (235642) | 235642..235699 | - | 58 | NuclAT_26 | - | - |
| MU414_RS01145 (235756) | 235756..235863 | + | 108 | WP_000170748.1 | type I toxin-antitoxin system toxin Ldr family protein | - |
| MU414_RS01150 (236239) | 236239..236346 | + | 108 | WP_001295224.1 | type I toxin-antitoxin system toxin Ldr family protein | - |
| MU414_RS01155 (236432) | 236432..238111 | - | 1680 | Protein_228 | cellulose biosynthesis protein BcsG | - |
| MU414_RS01160 (238108) | 238108..238299 | - | 192 | WP_000988308.1 | cellulose biosynthesis protein BcsF | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 336 a.a. Molecular weight: 38320.60 Da Isoelectric Point: 5.5965
>T241472 WP_001262467.1 NZ_CP095137:232502-233509 [Escherichia coli]
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLTPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDNKGLPVHQEQLDGAMQIMD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPALAPVYDFVSVAPY
PEYFHSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLTPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDNKGLPVHQEQLDGAMQIMD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPALAPVYDFVSVAPY
PEYFHSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL
Download Length: 1008 bp
>T241472 NZ_LT992470:907981-908169 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA
Antitoxin
Download Length: 104 a.a. Molecular weight: 11821.47 Da Isoelectric Point: 6.0609
>AT241472 WP_001312177.1 NZ_CP095137:232191-232502 [Escherichia coli]
MHRRVKVLLYGQVVGELSQNDSGFLFQYAPDYHGPAISISLPVAQRQFPSEMLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGMLIDNGKNLLGAIQILPWEE
MHRRVKVLLYGQVVGELSQNDSGFLFQYAPDYHGPAISISLPVAQRQFPSEMLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGMLIDNGKNLLGAIQILPWEE
Download Length: 312 bp
>AT241472 NZ_LT992470:907693-907953 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3K2ZTB5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3L3HKE2 |