Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 718976..719669 Replicon chromosome
Accession NZ_CP095125
Organism Escherichia coli strain Iso00270

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag MU416_RS03525 Protein ID WP_000415585.1
Coordinates 718976..719272 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag MU416_RS03530 Protein ID WP_000650107.1
Coordinates 719274..719669 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU416_RS03490 (714110) 714110..714589 + 480 WP_000065332.1 Hcp family type VI secretion system effector -
MU416_RS03495 (714592) 714592..715302 + 711 WP_000834030.1 hypothetical protein -
MU416_RS03500 (715309) 715309..715641 + 333 WP_000914690.1 DUF2645 family protein -
MU416_RS03505 (715687) 715687..717036 - 1350 WP_000673358.1 quorum sensing histidine kinase QseC -
MU416_RS03510 (717033) 717033..717692 - 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB -
MU416_RS03515 (717844) 717844..718236 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
MU416_RS03520 (718289) 718289..718771 + 483 WP_000183505.1 GyrI-like domain-containing protein -
MU416_RS03525 (718976) 718976..719272 + 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
MU416_RS03530 (719274) 719274..719669 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
MU416_RS03535 (719802) 719802..721409 + 1608 WP_001375094.1 ABC transporter substrate-binding protein -
MU416_RS03540 (721547) 721547..723805 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T241425 WP_000415585.1 NZ_CP095125:718976-719272 [Escherichia coli]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T241425 NZ_LT992464:c2313003-2312758 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT241425 WP_000650107.1 NZ_CP095125:719274-719669 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT241425 NZ_LT992464:2312424-2312789 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZN09

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References