Detailed information of TA system TA241405

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2587746..2588269
• Replicon: chromosome
• Accession: NZ_CP095119
• Organism: Staphylococcus aureus strain IVB6154

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: MUA68_RS13245
• Protein ID: WP_262520705.1
• Coordinates: 2587746..2588012 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: MUA68_RS13250
• Protein ID: WP_000587622.1
• Coordinates: 2588012..2588269 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA68_RS13225 (2582957)	2582957..2584144	-	1188	WP_262520701.1	MFS transporter	-
MUA68_RS13230 (2584537)	2584537..2585313	-	777	WP_000072151.1	iron export ABC transporter permease subunit FetB	-
MUA68_RS13235 (2585306)	2585306..2585968	-	663	WP_262520703.1	ATP-binding cassette domain-containing protein	-
MUA68_RS13240 (2586314)	2586314..2587390	-	1077	WP_262520704.1	M42 family metallopeptidase	-
MUA68_RS13245 (2587746)	2587746..2588012	-	267	WP_262520705.1	Txe/YoeB family addiction module toxin	Toxin
MUA68_RS13250 (2588012)	2588012..2588269	-	258	WP_000587622.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MUA68_RS13255 (2588628)	2588628..2589083	+	456	WP_259377214.1	DUF1307 domain-containing protein	-
MUA68_RS13260 (2589251)	2589251..2590828	-	1578	WP_262520706.1	FMN-binding glutamate synthase family protein	-
MUA68_RS13265 (2591021)	2591021..2591770	+	750	WP_262520707.1	CPBP family lipoprotein N-acylation protein LnsB	-
MUA68_RS13270 (2591994)	2591994..2593187	-	1194	WP_262520708.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (9-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10624.31 Da
• Isoelectric Point: 10.0798

>T241405 WP_262520705.1 NZ_CP095119:c2588012-2587746 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHPYLKKTFIEIVETLKNDPCKIIQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T241405 NZ_LT992462:c1901933-1901724 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATTTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9814.82 Da
• Isoelectric Point: 4.3304

>AT241405 WP_000587622.1 NZ_CP095119:c2588269-2588012 [Staphylococcus aureus]
MIITSPTEARKHFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT241405 NZ_LT992462:c1902238-1901945 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGAGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA