Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2587746..2588269 Replicon chromosome
Accession NZ_CP095119
Organism Staphylococcus aureus strain IVB6154

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag MUA68_RS13245 Protein ID WP_262520705.1
Coordinates 2587746..2588012 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag MUA68_RS13250 Protein ID WP_000587622.1
Coordinates 2588012..2588269 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA68_RS13225 (2582957) 2582957..2584144 - 1188 WP_262520701.1 MFS transporter -
MUA68_RS13230 (2584537) 2584537..2585313 - 777 WP_000072151.1 iron export ABC transporter permease subunit FetB -
MUA68_RS13235 (2585306) 2585306..2585968 - 663 WP_262520703.1 ATP-binding cassette domain-containing protein -
MUA68_RS13240 (2586314) 2586314..2587390 - 1077 WP_262520704.1 M42 family metallopeptidase -
MUA68_RS13245 (2587746) 2587746..2588012 - 267 WP_262520705.1 Txe/YoeB family addiction module toxin Toxin
MUA68_RS13250 (2588012) 2588012..2588269 - 258 WP_000587622.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA68_RS13255 (2588628) 2588628..2589083 + 456 WP_259377214.1 DUF1307 domain-containing protein -
MUA68_RS13260 (2589251) 2589251..2590828 - 1578 WP_262520706.1 FMN-binding glutamate synthase family protein -
MUA68_RS13265 (2591021) 2591021..2591770 + 750 WP_262520707.1 CPBP family lipoprotein N-acylation protein LnsB -
MUA68_RS13270 (2591994) 2591994..2593187 - 1194 WP_262520708.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10624.31 Da        Isoelectric Point: 10.0798

>T241405 WP_262520705.1 NZ_CP095119:c2588012-2587746 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHPYLKKTFIEIVETLKNDPCKIIQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T241405 NZ_LT992462:c1901933-1901724 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATTTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9814.82 Da        Isoelectric Point: 4.3304

>AT241405 WP_000587622.1 NZ_CP095119:c2588269-2588012 [Staphylococcus aureus]
MIITSPTEARKHFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT241405 NZ_LT992462:c1902238-1901945 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGAGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References