Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2556456..2556640 Replicon chromosome
Accession NZ_CP095119
Organism Staphylococcus aureus strain IVB6154

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2K4AFL5
Locus tag MUA68_RS13105 Protein ID WP_000482651.1
Coordinates 2556533..2556640 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2556456..2556516 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA68_RS13095 2552448..2554180 - 1733 Protein_2541 ABC transporter ATP-binding protein/permease -
MUA68_RS13100 2554205..2555968 - 1764 WP_262520678.1 ABC transporter ATP-binding protein -
- 2556456..2556516 + 61 - - Antitoxin
MUA68_RS13105 2556533..2556640 - 108 WP_000482651.1 type I toxin-antitoxin system Fst family toxin Toxin
MUA68_RS13110 2556774..2557160 - 387 WP_262520679.1 flippase GtxA -
MUA68_RS13115 2557428..2558570 + 1143 WP_262520680.1 glycerate kinase -
MUA68_RS13120 2558630..2559289 + 660 WP_000831298.1 membrane protein -
MUA68_RS13125 2559472..2560683 + 1212 WP_234727756.1 multidrug effflux MFS transporter -
MUA68_RS13130 2560806..2561279 - 474 WP_262520682.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3984.75 Da        Isoelectric Point: 11.0582

>T241403 WP_000482651.1 NZ_CP095119:c2556640-2556533 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRSNKKGDK

Download         Length: 108 bp

>T241403 NZ_LT992462:c1839425-1839330 [Staphylococcus aureus]
ATGTTGGAAATCCTTGTTCACATCACGACCACAGTCATCAGTGGTTGTATTATTGCGTTATTTACGCATTGGCTGCGTAA
TCGCAAAGACAAATAG

Antitoxin


Download         Length: 61 bp

>AT241403 NZ_CP095119:2556456-2556516 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTATTGCAGTAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K4AFL5

Antitoxin

Download structure file

References