241402

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2530831..2531348 Replicon chromosome
Accession NZ_CP095119
Organism Staphylococcus aureus strain IVB6154

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2S6D1N9
Locus tag MUA68_RS12970 Protein ID WP_000113263.1
Coordinates 2530831..2531097 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag MUA68_RS12975 Protein ID WP_000584499.1
Coordinates 2531097..2531348 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA68_RS12940 (2526031) 2526031..2526567 - 537 WP_262520654.1 GNAT family N-acetyltransferase -
MUA68_RS12945 (2527038) 2527038..2527862 - 825 WP_000594640.1 formate/nitrite transporter family protein -
MUA68_RS12950 (2528065) 2528065..2528247 - 183 WP_262520656.1 hypothetical protein -
MUA68_RS12955 (2528334) 2528334..2528801 - 468 WP_262520658.1 SRPBCC domain-containing protein -
MUA68_RS12960 (2528987) 2528987..2530537 - 1551 WP_262520659.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MUA68_RS12965 (2530725) 2530725..2530796 - 72 WP_262522083.1 hypothetical protein -
MUA68_RS12970 (2530831) 2530831..2531097 - 267 WP_000113263.1 Txe/YoeB family addiction module toxin Toxin
MUA68_RS12975 (2531097) 2531097..2531348 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA68_RS12980 (2531650) 2531650..2531751 - 102 Protein_2518 hypothetical protein -
MUA68_RS12985 (2531758) 2531758..2532357 - 600 WP_262520660.1 DsbA family protein -
MUA68_RS12990 (2532376) 2532376..2532738 - 363 WP_000819843.1 DUF4467 domain-containing protein -
MUA68_RS12995 (2532993) 2532993..2534201 + 1209 WP_262520661.1 FemA/FemB family glycyltransferase FmhA -
MUA68_RS13000 (2534298) 2534298..2535029 - 732 WP_262520662.1 amino acid ABC transporter ATP-binding protein -
MUA68_RS13005 (2535026) 2535026..2535745 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.01 Da        Isoelectric Point: 10.1628

>T241402 WP_000113263.1 NZ_CP095119:c2531097-2530831 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T241402 NZ_LT992462:c1697087-1696935 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT241402 WP_000584499.1 NZ_CP095119:c2531348-2531097 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT241402 NZ_LT992462:c1697711-1697112 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATGTAG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAACAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTTGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
CGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6D1N9

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References