Detailed information of TA system TA241400

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2275371..2275588
• Replicon: chromosome
• Accession: NZ_CP095119
• Organism: Staphylococcus aureus strain IVB6154

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: MUA68_RS11650
• Protein ID: WP_001802298.1
• Coordinates: 2275484..2275588 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2275371..2275426 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA68_RS11625	2271562..2272227	-	666	WP_262520450.1	SDR family oxidoreductase	-
MUA68_RS11630	2272379..2272699	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
MUA68_RS11635	2272701..2273678	+	978	WP_000019732.1	CDF family zinc efflux transporter CzrB	-
MUA68_RS11640	2273944..2275035	+	1092	WP_262520452.1	transcriptional regulator	-
-	2275371..2275426	+	56	-	-	Antitoxin
MUA68_RS11650	2275484..2275588	-	105	WP_001802298.1	hypothetical protein	Toxin
MUA68_RS11655	2275749..2276194	-	446	Protein_2262	recombinase family protein	-
MUA68_RS11660	2276294..2277426	-	1133	Protein_2263	SAP domain-containing protein	-
MUA68_RS11665	2278073..2278286	+	214	Protein_2264	exotoxin	-
MUA68_RS11670	2278473..2279330	-	858	WP_262520454.1	HAD family hydrolase	-
MUA68_RS11675	2279398..2280180	-	783	WP_262520455.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T241400 WP_001802298.1 NZ_CP095119:c2275588-2275484 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T241400 NZ_LT992462:c1334930-1334685 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 56 bp

>AT241400 NZ_CP095119:2275371-2275426 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin