Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 925441..925855 Replicon chromosome
Accession NZ_CP095119
Organism Staphylococcus aureus strain IVB6154

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MUA68_RS04740 Protein ID WP_262521614.1
Coordinates 925441..925692 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MUA68_RS04745 Protein ID WP_262521616.1
Coordinates 925682..925855 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA68_RS04690 (920765) 920765..921439 + 675 WP_262521605.1 putative HNHc nuclease -
MUA68_RS04695 (921432) 921432..922196 + 765 WP_262521606.1 DnaD domain protein -
MUA68_RS04700 (922196) 922196..922552 + 357 WP_197861636.1 hypothetical protein -
MUA68_RS04705 (922549) 922549..923790 + 1242 WP_115208674.1 DnaB helicase C-terminal domain-containing protein -
MUA68_RS04710 (923787) 923787..924002 + 216 WP_033842688.1 hypothetical protein -
MUA68_RS04715 (924005) 924005..924212 + 208 Protein_922 DUF3269 family protein -
MUA68_RS04720 (924223) 924223..924627 + 405 WP_262521609.1 DUF1064 domain-containing protein -
MUA68_RS04725 (924632) 924632..924817 + 186 WP_262521610.1 DUF3113 family protein -
MUA68_RS04730 (924818) 924818..925177 + 360 WP_262521612.1 SA1788 family PVL leukocidin-associated protein -
MUA68_RS04735 (925178) 925178..925426 + 249 WP_262521613.1 phi PVL orf 51-like protein -
MUA68_RS04740 (925441) 925441..925692 + 252 WP_262521614.1 DUF1024 family protein Toxin
MUA68_RS04745 (925682) 925682..925855 + 174 WP_262521616.1 hypothetical protein Antitoxin
MUA68_RS04750 (925856) 925856..926137 + 282 WP_000454994.1 hypothetical protein -
MUA68_RS04755 (926138) 926138..926299 + 162 WP_000889682.1 hypothetical protein -
MUA68_RS04760 (926314) 926314..926832 + 519 WP_262521618.1 dUTPase -
MUA68_RS04765 (926869) 926869..927111 + 243 WP_000028780.1 hypothetical protein -
MUA68_RS04770 (927108) 927108..927314 + 207 WP_000195803.1 DUF1381 domain-containing protein -
MUA68_RS04775 (927311) 927311..927697 + 387 WP_262521619.1 DUF1523 family protein -
MUA68_RS04780 (927694) 927694..927843 + 150 WP_000595265.1 transcriptional activator RinB -
MUA68_RS04785 (928002) 928002..928418 + 417 WP_262521620.1 hypothetical protein -
MUA68_RS04790 (928651) 928651..928851 + 201 WP_164817139.1 DUF1514 family protein -
MUA68_RS04795 (928879) 928879..929295 + 417 WP_262521621.1 transcriptional regulator -
MUA68_RS04800 (929526) 929526..929825 + 300 WP_000988332.1 HNH endonuclease -
MUA68_RS04805 (929955) 929955..930299 + 345 WP_000402904.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9431.36 Da        Isoelectric Point: 3.9476

>T241388 WP_262521614.1 NZ_CP095119:925441-925692 [Staphylococcus aureus]
MKNREQIEQSVISASAYNGNDTEGLLKEIEDVYKRAQAFDEILEGMTNAIQHSVKEGIELDEAVGIMAGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T241388 NZ_LT992461:c290734-290525 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATTTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6540.35 Da        Isoelectric Point: 4.1623

>AT241388 WP_262521616.1 NZ_CP095119:925682-925855 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVEDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT241388 NZ_LT992461:c291039-290746 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGAGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References