Detailed information of TA system TA241384

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 823505..824084
• Replicon: chromosome
• Accession: NZ_CP095119
• Organism: Staphylococcus aureus strain IVB6154

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: -
• Locus tag: MUA68_RS03970
• Protein ID: WP_001025400.1
• Coordinates: 823505..823738 (+)
• Length: 78 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	823720..824084 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA68_RS03935	818802..819266	+	465	WP_262521493.1	SsrA-binding protein SmpB	-
MUA68_RS03945	819778..820827	-	1050	WP_262521494.1	site-specific integrase	-
MUA68_RS03950	820914..821642	-	729	WP_000733771.1	staphylococcal enterotoxin type K	-
MUA68_RS03955	821666..822394	-	729	WP_262521495.1	staphylococcal enterotoxin type Q	-
MUA68_RS03960	822450..823076	-	627	WP_078104124.1	XRE family transcriptional regulator	-
MUA68_RS03965	823274..823489	+	216	WP_000916582.1	hypothetical protein	-
MUA68_RS03970	823505..823738	+	234	WP_001025400.1	DUF2829 domain-containing protein	Toxin
-	823720..824084	-	365	-	-	Antitoxin
MUA68_RS03980	824140..824877	+	738	WP_262521496.1	BRO family protein	-
MUA68_RS03985	824889..825098	+	210	WP_262521497.1	hypothetical protein	-
MUA68_RS03990	825111..825272	+	162	WP_000066011.1	DUF1270 domain-containing protein	-
MUA68_RS03995	825366..825626	+	261	WP_262521498.1	DUF1108 family protein	-
MUA68_RS04000	825636..825857	+	222	WP_000815402.1	DUF2483 family protein	-
MUA68_RS04005	825850..826473	+	624	WP_000139725.1	DUF1071 domain-containing protein	-
MUA68_RS04010	826473..826907	+	435	WP_262521499.1	single-stranded DNA-binding protein	-
MUA68_RS04015	826919..827587	+	669	WP_262521500.1	putative HNHc nuclease	-
MUA68_RS04020	827773..828183	-	411	WP_262521501.1	hypothetical protein	-
MUA68_RS04025	828245..828982	+	738	WP_262521502.1	conserved phage C-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / selq / seb / sell	816408..879621	63213

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 78 a.a.
• Molecular weight: 8964.13 Da
• Isoelectric Point: 4.9847

>T241384 WP_001025400.1 NZ_CP095119:823505-823738 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPIRDQEL

Nucleotide

• Length: 234 bp

>T241384 NZ_LT992460:c2738399-2738292 [Staphylococcus aureus]
GTGATATCTATTGCAAATGCATTACATTTAATGTTAAGTTTCGGTATGTTTATCGTCACTTTCATTGGTGTAGTAGTCGC
AATAATTAATTTAAACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 365 bp

>AT241384 NZ_CP095119:c824084-823720 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAATCAGGTTCTGTTAAATTAAGTTGTAATAATTTCGATGATGCTGAAGGTATACATTTAAAGTATTTTC
AAAAATTGCATTTCGAAGATGTCGACAACGATTTAAAAAAACTTAAAAATTCCGGATTCCTCCACGGTGTGCTTGCAGAC
AACACTATTTATCATGTAACAATTTCAGACAAGACTATTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCTATAATTCCTGGTCTCTA

Structures

Antitoxin