Detailed information of TA system TA241382

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF1/-
• Location: 340415..340936
• Replicon: chromosome
• Accession: NZ_CP095119
• Organism: Staphylococcus aureus strain IVB6154

Toxin (Protein)

• Gene name: holin
• Uniprot ID: A0A2S6DEP6
• Locus tag: MUA68_RS01550
• Protein ID: WP_000339141.1
• Coordinates: 340634..340936 (+)
• Length: 101 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	340415..340554 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA68_RS01525 (339188)	339188..339340	+	153	WP_001153680.1	hypothetical protein	-
MUA68_RS01530 (339387)	339387..339674	+	288	WP_001040259.1	hypothetical protein	-
MUA68_RS01535 (339730)	339730..340104	+	375	WP_262521123.1	hypothetical protein	-
MUA68_RS01540 (340247)	340247..340423	+	177	WP_072357969.1	type I toxin-antitoxin system toxin PepG1	-
- (340415)	340415..340554	-	140	NuclAT_1	-	Antitoxin
- (340415)	340415..340554	-	140	NuclAT_1	-	Antitoxin
- (340415)	340415..340554	-	140	NuclAT_1	-	Antitoxin
- (340415)	340415..340554	-	140	NuclAT_1	-	Antitoxin
MUA68_RS01545 (340476)	340476..340583	-	108	WP_042900009.1	hypothetical protein	-
MUA68_RS01550 (340634)	340634..340936	+	303	WP_000339141.1	phage holin	Toxin
MUA68_RS01555 (340947)	340947..342401	+	1455	WP_262521125.1	N-acetylmuramoyl-L-alanine amidase	-
MUA68_RS01560 (343497)	343497..343883	+	387	WP_262521126.1	hypothetical protein	-
MUA68_RS01565 (344443)	344443..345270	-	828	WP_262521128.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	303389..342401	39012

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (1-71)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11174.92 Da
• Isoelectric Point: 9.6413

>T241382 WP_000339141.1 NZ_CP095119:340634-340936 [Staphylococcus aureus]
MDAKVITRYIVLILALVNQFLANKGISPIPVDDETISSIILTVVALYTTYKDNPTSQEGKWANQKLKKYKAENKYRKATG
QAPIKEVMTPTNMNDTNDLG

Nucleotide

• Length: 303 bp

>T241382 NZ_LT992460:1648272-1648634 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAACAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAGCAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTAAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin

Nucleotide

• Length: 140 bp

>AT241382 NZ_CP095119:c340554-340415 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGTGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• AlphaFold DB: A0A2S6DEP6

Antitoxin