Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2500785..2501383 Replicon chromosome
Accession NC_012969
Organism Methylovorus glucosetrophus SIP3-4

Toxin (Protein)


Gene name graT Uniprot ID C6XA68
Locus tag MSIP34_RS11900 Protein ID WP_015830899.1
Coordinates 2501102..2501383 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID C6XA67
Locus tag MSIP34_RS11895 Protein ID WP_015830898.1
Coordinates 2500785..2501090 (-) Length 102 a.a.

Genomic Context

MSIP34_RS11875MSIP34_RS11880MSIP34_RS11885MSIP34_RS11890MSIP34_RS14975MSIP34_RS11895MSIP34_RS11900MSIP34_RS11905MSIP34_RS11910MSIP34_RS11915MSIP34_RS11920MSIP34_RS11925MSIP34_RS11930MSIP34_RS11935MSIP34_RS15280MSIP34_RS11945
Location: 2496966..2497724 (759 bp)
Type: Others
Protein ID: WP_015830894.1
Location: 2497743..2498495 (753 bp)
Type: Others
Protein ID: WP_148211187.1
Location: 2498509..2499174 (666 bp)
Type: Others
Protein ID: WP_015830896.1
Location: 2499150..2500496 (1347 bp)
Type: Others
Protein ID: WP_015830897.1
Location: 2501642..2501833 (192 bp)
Type: Others
Protein ID: WP_083773324.1
Location: 2500785..2501090 (306 bp)
Type: Antitoxin
Protein ID: WP_015830898.1
Location: 2501102..2501383 (282 bp)
Type: Toxin
Protein ID: WP_015830899.1
Location: 2501883..2502104 (222 bp)
Type: Others
Protein ID: WP_015830900.1
Location: 2502108..2502461 (354 bp)
Type: Others
Protein ID: WP_041370182.1
Location: 2502577..2502756 (180 bp)
Type: Others
Protein ID: WP_041370184.1
Location: 2502763..2503041 (279 bp)
Type: Others
Protein ID: WP_015830902.1
Location: 2503105..2503497 (393 bp)
Type: Others
Protein ID: WP_015830903.1
Location: 2503508..2504626 (1119 bp)
Type: Others
Protein ID: WP_015830904.1
Location: 2504653..2504973 (321 bp)
Type: Others
Protein ID: WP_015830905.1
Location: 2504970..2505227 (258 bp)
Type: Others
Protein ID: WP_041370186.1
Location: 2505224..2506261 (1038 bp)
Type: Others
Protein ID: WP_015830906.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MSIP34_RS118752496966..2497724+759WP_015830894.1membrane protein-
MSIP34_RS118802497743..2498495+753WP_148211187.1hypothetical protein-
MSIP34_RS118852498509..2499174+666WP_015830896.1response regulator transcription factor-
MSIP34_RS118902499150..2500496+1347WP_015830897.1HAMP domain-containing histidine kinase-
MSIP34_RS118952500785..2501090-306WP_015830898.1HigA family addiction module antidote proteinAntitoxin
MSIP34_RS119002501102..2501383-282WP_015830899.1type II toxin-antitoxin system RelE/ParE family toxinToxin
MSIP34_RS149752501642..2501833+192WP_083773324.1type II toxin-antitoxin system MqsA family antitoxin-
MSIP34_RS119052501883..2502104-222WP_015830900.1hypothetical protein-
MSIP34_RS119102502108..2502461-354WP_041370182.1hypothetical protein-
MSIP34_RS119152502577..2502756-180WP_041370184.1hypothetical protein-
MSIP34_RS119202502763..2503041-279WP_015830902.1addiction module antidote protein-
MSIP34_RS119252503105..2503497-393WP_015830903.1hypothetical protein-
MSIP34_RS119302503508..2504626-1119WP_015830904.1type IV secretion system protein-
MSIP34_RS119352504653..2504973-321WP_015830905.1hypothetical protein-
MSIP34_RS152802504970..2505227-258WP_041370186.1hypothetical protein-
MSIP34_RS119452505224..2506261-1038WP_015830906.1relaxase/mobilization nuclease domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(24-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-96)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10835.32 Da        Isoelectric Point: 6.7097

>T24138 WP_015830899.1 NC_012969:c2501383-2501102 [Methylovorus glucosetrophus SIP3-4]
MTIQTFLCQDTQDIYEGKHPRRFRNIEAVAERKLQMLDAAVELKDLRSPPGNRLEALIGDRAGQHSIRINDQWRICFVWT
ATGPDRVEIVDYH

Download         Length: 282 bp

>T24138 NC_012969:c2501383-2501102 [Methylovorus glucosetrophus SIP3-4]
ATGACGATCCAAACATTCCTGTGCCAGGACACCCAAGATATTTATGAAGGGAAACATCCTAGAAGGTTCAGAAATATCGA
GGCAGTCGCCGAGCGAAAGCTTCAAATGCTGGATGCAGCTGTCGAGCTGAAAGATTTGCGTTCACCGCCAGGCAATAGGC
TGGAAGCGCTAATCGGTGATCGGGCTGGTCAGCACAGCATACGCATCAATGACCAGTGGCGCATTTGCTTTGTGTGGACA
GCGACAGGCCCTGATCGTGTTGAGATCGTCGATTACCATTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11477.18 Da        Isoelectric Point: 7.3190

>AT24138 WP_015830898.1 NC_012969:c2501090-2500785 [Methylovorus glucosetrophus SIP3-4]
MATNNMRPIHPGEILREEYLVPLEMSGHALSIELRVPATKINDILRARRAVTSDTALRLSRFFGTTPQFWANLQSAYDLK
QAEIAHGKEIEQQVRQMDMAA

Download         Length: 306 bp

>AT24138 NC_012969:c2501090-2500785 [Methylovorus glucosetrophus SIP3-4]
ATGGCAACCAACAATATGAGACCAATTCATCCGGGCGAGATTCTGCGCGAGGAGTATCTTGTGCCTCTCGAAATGAGCGG
TCATGCCCTTTCTATTGAGCTGCGCGTCCCCGCGACTAAAATCAATGACATTTTGCGAGCACGCCGTGCTGTTACATCTG
ACACCGCTTTGCGGTTGTCGCGGTTCTTCGGAACGACCCCGCAGTTTTGGGCAAACCTGCAAAGTGCATATGATTTGAAG
CAGGCTGAGATAGCCCATGGCAAAGAGATCGAGCAGCAGGTCAGACAGATGGATATGGCCGCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBC6XA68

Antitoxin

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Source
ID
Structure
AlphaFold DBC6XA67

References