Detailed information of TA system TA241379

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 340247..340585
• Replicon: chromosome
• Accession: NZ_CP095119
• Organism: Staphylococcus aureus strain IVB6154

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: MUA68_RS01540
• Protein ID: WP_072357969.1
• Coordinates: 340247..340423 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	340411..340585 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA68_RS01520	335413..339198	+	3786	WP_262520278.1	phage tail spike protein	-
MUA68_RS01525	339188..339340	+	153	WP_001153680.1	hypothetical protein	-
MUA68_RS01530	339387..339674	+	288	WP_001040259.1	hypothetical protein	-
MUA68_RS01535	339730..340104	+	375	WP_262521123.1	hypothetical protein	-
MUA68_RS01540	340247..340423	+	177	WP_072357969.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	340411..340585	-	175	-	-	Antitoxin
MUA68_RS01550	340634..340936	+	303	WP_000339141.1	phage holin	-
MUA68_RS01555	340947..342401	+	1455	WP_262521125.1	N-acetylmuramoyl-L-alanine amidase	-
MUA68_RS01560	343497..343883	+	387	WP_262521126.1	hypothetical protein	-
MUA68_RS01565	344443..345270	-	828	WP_262521128.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	303389..342401	39012

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T241379 WP_072357969.1 NZ_CP095119:340247-340423 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T241379 NZ_LT992460:1274078-1274185 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT241379 NZ_CP095119:c340585-340411 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGTGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin