Detailed information of TA system TA241377

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2548782..2548966
• Replicon: chromosome
• Accession: NZ_CP095116
• Organism: Staphylococcus aureus strain IVB6156

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: MUA78_RS12835
• Protein ID: WP_000482647.1
• Coordinates: 2548859..2548966 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2548782..2548842 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA78_RS12820	2544236..2544403	-	168	WP_031901225.1	hypothetical protein	-
MUA78_RS12825	2544634..2546367	-	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
MUA78_RS12830	2546392..2548155	-	1764	Protein_2487	ABC transporter ATP-binding protein/permease	-
-	2548782..2548842	+	61	-	-	Antitoxin
MUA78_RS12835	2548859..2548966	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
MUA78_RS12840	2549100..2549486	-	387	WP_000779350.1	flippase GtxA	-
MUA78_RS12845	2549754..2550896	+	1143	WP_001176867.1	glycerate kinase	-
MUA78_RS12850	2550956..2551615	+	660	WP_000831298.1	membrane protein	-
MUA78_RS12855	2551798..2553009	+	1212	WP_001191927.1	multidrug effflux MFS transporter	-
MUA78_RS12860	2553132..2553605	-	474	WP_000456488.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1024 (1-82)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T241377 WP_000482647.1 NZ_CP095116:c2548966-2548859 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T241377 NZ_LT992460:c210412-210161 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCAGTTATAAGTGCTAGTGCGTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTTTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGCATTAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT241377 NZ_CP095116:2548782-2548842 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin