Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2523479..2523996 Replicon chromosome
Accession NZ_CP095116
Organism Staphylococcus aureus strain IVB6156

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag MUA78_RS12700 Protein ID WP_000113259.1
Coordinates 2523479..2523745 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag MUA78_RS12705 Protein ID WP_000584500.1
Coordinates 2523745..2523996 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA78_RS12670 (2518708) 2518708..2519244 - 537 WP_000185899.1 GNAT family N-acetyltransferase -
MUA78_RS12675 (2519688) 2519688..2520512 - 825 WP_000594633.1 formate/nitrite transporter family protein -
MUA78_RS12680 (2520715) 2520715..2520897 - 183 WP_000079140.1 hypothetical protein -
MUA78_RS12685 (2520984) 2520984..2521451 - 468 WP_262515210.1 SRPBCC domain-containing protein -
MUA78_RS12690 (2521637) 2521637..2523184 - 1548 WP_000727756.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MUA78_RS12695 (2523373) 2523373..2523462 - 90 Protein_2460 hypothetical protein -
MUA78_RS12700 (2523479) 2523479..2523745 - 267 WP_000113259.1 Txe/YoeB family addiction module toxin Toxin
MUA78_RS12705 (2523745) 2523745..2523996 - 252 WP_000584500.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA78_RS12710 (2524160) 2524160..2524240 - 81 WP_224085678.1 hypothetical protein -
MUA78_RS12715 (2524268) 2524268..2524867 - 600 WP_000162810.1 DsbA family protein -
MUA78_RS12720 (2524886) 2524886..2525248 - 363 WP_000819848.1 DUF4467 domain-containing protein -
MUA78_RS12725 (2525503) 2525503..2526753 + 1251 WP_001012232.1 FemA/FemB family glycyltransferase FmhA -
MUA78_RS12730 (2526850) 2526850..2527581 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
MUA78_RS12735 (2527578) 2527578..2528297 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10464.08 Da        Isoelectric Point: 10.2538

>T241376 WP_000113259.1 NZ_CP095116:c2523745-2523479 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYKVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T241376 NZ_LT992460:c186980-186804 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9419.58 Da        Isoelectric Point: 4.3407

>AT241376 WP_000584500.1 NZ_CP095116:c2523996-2523745 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT241376 NZ_LT992460:186681-186736 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References