Detailed information of TA system TA241362

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF1/-
• Location: 371938..372459
• Replicon: chromosome
• Accession: NZ_CP095116
• Organism: Staphylococcus aureus strain IVB6156

Toxin (Protein)

• Gene name: holin
• Uniprot ID: A0A2S6DEP6
• Locus tag: MUA78_RS01675
• Protein ID: WP_000339141.1
• Coordinates: 372157..372459 (+)
• Length: 101 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	371938..372077 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA78_RS01635 (367045)	367045..367335	+	291	WP_000179864.1	hypothetical protein	-
MUA78_RS01640 (367351)	367351..369261	+	1911	WP_262515309.1	hypothetical protein	-
MUA78_RS01645 (369261)	369261..370727	+	1467	WP_250414780.1	BppU family phage baseplate upper protein	-
MUA78_RS01650 (370727)	370727..371116	+	390	WP_250406125.1	DUF2977 domain-containing protein	-
MUA78_RS01655 (371109)	371109..371273	+	165	WP_000916021.1	XkdX family protein	-
MUA78_RS01660 (371319)	371319..371617	+	299	Protein_329	DUF2951 domain-containing protein	-
MUA78_RS01665 (371770)	371770..371946	+	177	WP_072357969.1	type I toxin-antitoxin system toxin PepG1	-
- (371938)	371938..372077	-	140	NuclAT_0	-	Antitoxin
- (371938)	371938..372077	-	140	NuclAT_0	-	Antitoxin
- (371938)	371938..372077	-	140	NuclAT_0	-	Antitoxin
- (371938)	371938..372077	-	140	NuclAT_0	-	Antitoxin
MUA78_RS01670 (371999)	371999..372106	-	108	WP_042900009.1	hypothetical protein	-
MUA78_RS01675 (372157)	372157..372459	+	303	WP_000339141.1	phage holin	Toxin
MUA78_RS01680 (372470)	372470..373924	+	1455	WP_250414789.1	N-acetylmuramoyl-L-alanine amidase	-
MUA78_RS01685 (375018)	375018..375404	+	387	WP_228480554.1	hypothetical protein	-
MUA78_RS01690 (375964)	375964..376791	-	828	WP_000136010.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	329253..373924	44671

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (1-71)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11174.92 Da
• Isoelectric Point: 9.6413

>T241362 WP_000339141.1 NZ_CP095116:372157-372459 [Staphylococcus aureus]
MDAKVITRYIVLILALVNQFLANKGISPIPVDDETISSIILTVVALYTTYKDNPTSQEGKWANQKLKKYKAENKYRKATG
QAPIKEVMTPTNMNDTNDLG

Nucleotide

• Length: 303 bp

>T241362 NZ_LT992456:2005508-2005870 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAACAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAGCAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTAAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin

Nucleotide

• Length: 140 bp

>AT241362 NZ_CP095116:c372077-371938 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGTGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• AlphaFold DB: A0A2S6DEP6

Antitoxin