Detailed information of TA system TA241361

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF/-
• Location: 371770..372077
• Replicon: chromosome
• Accession: NZ_CP095116
• Organism: Staphylococcus aureus strain IVB6156

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: MUA78_RS01665
• Protein ID: WP_072357969.1
• Coordinates: 371770..371946 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF
Locus tag	-
Coordinates	371936..372077 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA78_RS01635	367045..367335	+	291	WP_000179864.1	hypothetical protein	-
MUA78_RS01640	367351..369261	+	1911	WP_262515309.1	hypothetical protein	-
MUA78_RS01645	369261..370727	+	1467	WP_250414780.1	BppU family phage baseplate upper protein	-
MUA78_RS01650	370727..371116	+	390	WP_250406125.1	DUF2977 domain-containing protein	-
MUA78_RS01655	371109..371273	+	165	WP_000916021.1	XkdX family protein	-
MUA78_RS01660	371319..371617	+	299	Protein_329	DUF2951 domain-containing protein	-
MUA78_RS01665	371770..371946	+	177	WP_072357969.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	371936..372077	-	142	-	-	Antitoxin
MUA78_RS01675	372157..372459	+	303	WP_000339141.1	phage holin	-
MUA78_RS01680	372470..373924	+	1455	WP_250414789.1	N-acetylmuramoyl-L-alanine amidase	-
MUA78_RS01685	375018..375404	+	387	WP_228480554.1	hypothetical protein	-
MUA78_RS01690	375964..376791	-	828	WP_000136010.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	329253..373924	44671

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T241361 WP_072357969.1 NZ_CP095116:371770-371946 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T241361 NZ_LT992456:1985924-1986133 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATTTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Nucleotide

• Length: 142 bp

>AT241361 NZ_CP095116:c372077-371936 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGTGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTTAT

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin