Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2527184..2527368 Replicon chromosome
Accession NZ_CP095112
Organism Staphylococcus aureus strain IVB6157

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag MUA55_RS12635 Protein ID WP_000482647.1
Coordinates 2527261..2527368 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2527184..2527244 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA55_RS12620 (MUA55_12625) 2522694..2522861 - 168 Protein_2442 hypothetical protein -
MUA55_RS12625 (MUA55_12630) 2523092..2524825 - 1734 WP_000486505.1 ABC transporter ATP-binding protein -
MUA55_RS12630 (MUA55_12635) 2524850..2526613 - 1764 WP_001064829.1 ABC transporter ATP-binding protein -
- 2527184..2527244 + 61 - - Antitoxin
MUA55_RS12635 (MUA55_12640) 2527261..2527368 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
MUA55_RS12640 (MUA55_12645) 2527502..2527888 - 387 WP_000779351.1 flippase GtxA -
MUA55_RS12645 (MUA55_12650) 2528156..2529298 + 1143 WP_001176855.1 glycerate kinase -
MUA55_RS12650 (MUA55_12655) 2529358..2530017 + 660 WP_000831298.1 membrane protein -
MUA55_RS12655 (MUA55_12660) 2530199..2531410 + 1212 WP_001191919.1 multidrug effflux MFS transporter -
MUA55_RS12660 (MUA55_12665) 2531533..2532006 - 474 WP_000456496.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T241356 WP_000482647.1 NZ_CP095112:c2527368-2527261 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T241356 NZ_LT992436:c2590124-2589936 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 61 bp

>AT241356 NZ_CP095112:2527184-2527244 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References