Detailed information of TA system TA241355

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2501883..2502400
• Replicon: chromosome
• Accession: NZ_CP095112
• Organism: Staphylococcus aureus strain IVB6157

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A170NWK0
• Locus tag: MUA55_RS12500
• Protein ID: WP_000251928.1
• Coordinates: 2501883..2502149 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A166LMC5
• Locus tag: MUA55_RS12505
• Protein ID: WP_000584497.1
• Coordinates: 2502149..2502400 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA55_RS12475 (MUA55_12480)	2497090..2497626	-	537	WP_000024292.1	GNAT family N-acetyltransferase	-
MUA55_RS12480 (MUA55_12485)	2498094..2498918	-	825	WP_000594640.1	formate/nitrite transporter family protein	-
MUA55_RS12485 (MUA55_12490)	2499121..2499303	-	183	WP_000079140.1	hypothetical protein	-
MUA55_RS12490 (MUA55_12495)	2499390..2499857	-	468	WP_250396336.1	SRPBCC domain-containing protein	-
MUA55_RS12495 (MUA55_12500)	2500043..2501590	-	1548	WP_045179540.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
MUA55_RS12500 (MUA55_12505)	2501883..2502149	-	267	WP_000251928.1	Txe/YoeB family addiction module toxin	Toxin
MUA55_RS12505 (MUA55_12510)	2502149..2502400	-	252	WP_000584497.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MUA55_RS12510 (MUA55_12515)	2502564..2502664	-	101	Protein_2420	hypothetical protein	-
MUA55_RS12515 (MUA55_12520)	2502671..2503270	-	600	WP_000162804.1	DsbA family protein	-
MUA55_RS12520 (MUA55_12525)	2503289..2503651	-	363	WP_000819843.1	DUF4467 domain-containing protein	-
MUA55_RS12525 (MUA55_12530)	2503906..2505156	+	1251	WP_001012237.1	FemA/FemB family glycyltransferase FmhA	-
MUA55_RS12530 (MUA55_12535)	2505253..2505984	-	732	WP_000615467.1	amino acid ABC transporter ATP-binding protein	-
MUA55_RS12535 (MUA55_12540)	2505981..2506700	-	720	WP_000479573.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10465.06 Da
• Isoelectric Point: 10.1628

>T241355 WP_000251928.1 NZ_CP095112:c2502149-2501883 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T241355 NZ_LT992436:2560798-2561115 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGTATCAGATGACGCACAAAAATTAAAAATCACAGAGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9401.54 Da
• Isoelectric Point: 4.3407

>AT241355 WP_000584497.1 NZ_CP095112:c2502400-2502149 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Nucleotide

• Length: 252 bp

>AT241355 NZ_LT992436:2560586-2560795 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATAGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: A0A170NWK0

Antitoxin

• AlphaFold DB: A0A166LMC5