Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF3/-
Location 1582786..1583077 Replicon chromosome
Accession NZ_CP095112
Organism Staphylococcus aureus strain IVB6157

Toxin (Protein)


Gene name txpA Uniprot ID -
Locus tag MUA55_RS07580 Protein ID WP_252559492.1
Coordinates 1582901..1583077 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 1582786..1582842 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA55_RS07540 (MUA55_07545) 1577861..1578007 - 147 WP_001033756.1 hypothetical protein -
MUA55_RS07545 (MUA55_07550) 1578000..1578914 - 915 WP_000476887.1 DUF1672 domain-containing protein -
MUA55_RS07550 (MUA55_07555) 1578972..1579877 - 906 WP_000913238.1 DUF1672 domain-containing protein -
MUA55_RS07555 (MUA55_07560) 1579967..1580182 - 216 WP_262518166.1 hypothetical protein -
MUA55_RS07560 (MUA55_07565) 1580995..1581486 - 492 WP_252559491.1 staphylokinase -
MUA55_RS07565 (MUA55_07570) 1581676..1582431 - 756 WP_252559490.1 CHAP domain-containing protein -
MUA55_RS07570 (MUA55_07575) 1582443..1582697 - 255 WP_238522769.1 phage holin -
MUA55_RS07575 (MUA55_07580) 1582749..1582849 + 101 Protein_1486 hypothetical protein -
- 1582786..1582842 + 57 - - Antitoxin
MUA55_RS07580 (MUA55_07585) 1582901..1583077 - 177 WP_252559492.1 type I toxin-antitoxin system toxin PepG1 Toxin
MUA55_RS07585 (MUA55_07590) 1583278..1584057 - 780 WP_262518171.1 exotoxin -
MUA55_RS07590 (MUA55_07595) 1584512..1584886 - 375 WP_252559488.1 hypothetical protein -
MUA55_RS07595 (MUA55_07600) 1584942..1585229 - 288 WP_162636283.1 hypothetical protein -
MUA55_RS07600 (MUA55_07605) 1585275..1585427 - 153 WP_001153681.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sak / sea / gnd 1576866..1649101 72235


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6818.48 Da        Isoelectric Point: 10.9678

>T241347 WP_252559492.1 NZ_CP095112:c1583077-1582901 [Staphylococcus aureus]
MDRWRLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSIKK

Download         Length: 177 bp

>T241347 NZ_LT992435:c1446745-1446638 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 57 bp

>AT241347 NZ_CP095112:1582786-1582842 [Staphylococcus aureus]
AAAAGGGCAACATGCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References