Detailed information of TA system TA241345

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2582612..2583135
• Replicon: chromosome
• Accession: NZ_CP095109
• Organism: Staphylococcus aureus strain IVB6171

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: MUA24_RS13225
• Protein ID: WP_262533011.1
• Coordinates: 2582612..2582878 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A2S6D1W5
• Locus tag: MUA24_RS13230
• Protein ID: WP_000587617.1
• Coordinates: 2582878..2583135 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA24_RS13205 (MUA24_13160)	2577820..2579007	-	1188	WP_045157510.1	MFS transporter	-
MUA24_RS13210 (MUA24_13165)	2579401..2580177	-	777	WP_262533007.1	iron export ABC transporter permease subunit FetB	-
MUA24_RS13215 (MUA24_13170)	2580170..2580832	-	663	WP_262533008.1	ATP-binding cassette domain-containing protein	-
MUA24_RS13220 (MUA24_13175)	2581179..2582255	-	1077	WP_262533009.1	M42 family metallopeptidase	-
MUA24_RS13225 (MUA24_13180)	2582612..2582878	-	267	WP_262533011.1	Txe/YoeB family addiction module toxin	Toxin
MUA24_RS13230 (MUA24_13185)	2582878..2583135	-	258	WP_000587617.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MUA24_RS13235 (MUA24_13190)	2583494..2583949	+	456	WP_262533012.1	DUF1307 domain-containing protein	-
MUA24_RS13240 (MUA24_13195)	2584117..2585694	-	1578	WP_262533014.1	FMN-binding glutamate synthase family protein	-
MUA24_RS13245 (MUA24_13200)	2585890..2586639	+	750	WP_262533015.1	CPBP family lipoprotein N-acylation protein LnsB	-
MUA24_RS13250 (MUA24_13205)	2586863..2588056	-	1194	WP_262533016.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10620.41 Da
• Isoelectric Point: 10.2052

>T241345 WP_262533011.1 NZ_CP095109:c2582878-2582612 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHPYLKKIFIEIVETLKNDPCKIIQSFEKLEPKYLERYSRRINHQHRVVYTIDDRNKVVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T241345 NZ_LT992435:c1084220-1083858 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAGCAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9747.71 Da
• Isoelectric Point: 4.1353

>AT241345 WP_000587617.1 NZ_CP095109:c2583135-2582878 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT241345 NZ_LT992435:c1084387-1084217 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A2S6D1W5