Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2551315..2551499 Replicon chromosome
Accession NZ_CP095109
Organism Staphylococcus aureus strain IVB6171

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2K4AFL5
Locus tag MUA24_RS13080 Protein ID WP_000482651.1
Coordinates 2551392..2551499 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2551315..2551375 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA24_RS13065 (MUA24_13020) 2546691..2546858 - 168 WP_041204334.1 hypothetical protein -
MUA24_RS13070 (MUA24_13025) 2547089..2548881 - 1793 Protein_2537 ABC transporter ATP-binding protein/permease -
MUA24_RS13075 (MUA24_13030) 2548906..2550669 - 1764 WP_262532983.1 ABC transporter ATP-binding protein -
- 2551315..2551375 + 61 - - Antitoxin
MUA24_RS13080 (MUA24_13035) 2551392..2551499 - 108 WP_000482651.1 type I toxin-antitoxin system Fst family toxin Toxin
MUA24_RS13085 (MUA24_13040) 2551633..2552019 - 387 WP_262520679.1 flippase GtxA -
MUA24_RS13090 (MUA24_13045) 2552302..2553429 + 1128 WP_262534633.1 glycerate kinase -
MUA24_RS13095 (MUA24_13050) 2553489..2554148 + 660 WP_000831298.1 membrane protein -
MUA24_RS13100 (MUA24_13055) 2554330..2555541 + 1212 WP_234727756.1 multidrug effflux MFS transporter -
MUA24_RS13105 (MUA24_13060) 2555664..2556137 - 474 WP_262532984.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3984.75 Da        Isoelectric Point: 11.0582

>T241343 WP_000482651.1 NZ_CP095109:c2551499-2551392 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRSNKKGDK

Download         Length: 108 bp

>T241343 NZ_LT992435:c890172-890020 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGAGAGTCAGTAA

Antitoxin


Download         Length: 61 bp

>AT241343 NZ_CP095109:2551315-2551375 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTATTGCCGTAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K4AFL5

Antitoxin

Download structure file

References