Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2527298..2527815 Replicon chromosome
Accession NZ_CP095109
Organism Staphylococcus aureus strain IVB6171

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag MUA24_RS12950 Protein ID WP_262532957.1
Coordinates 2527298..2527564 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag MUA24_RS12955 Protein ID WP_262532958.1
Coordinates 2527564..2527815 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA24_RS12920 (MUA24_12875) 2522501..2523037 - 537 WP_000185901.1 GNAT family N-acetyltransferase -
MUA24_RS12925 (MUA24_12880) 2523505..2524329 - 825 WP_000594640.1 formate/nitrite transporter family protein -
MUA24_RS12930 (MUA24_12885) 2524532..2524714 - 183 WP_000079140.1 hypothetical protein -
MUA24_RS12935 (MUA24_12890) 2524801..2525268 - 468 WP_000153344.1 SRPBCC domain-containing protein -
MUA24_RS12940 (MUA24_12895) 2525454..2527004 - 1551 WP_262532956.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MUA24_RS12945 (MUA24_12900) 2527192..2527263 - 72 WP_262534631.1 hypothetical protein -
MUA24_RS12950 (MUA24_12905) 2527298..2527564 - 267 WP_262532957.1 Txe/YoeB family addiction module toxin Toxin
MUA24_RS12955 (MUA24_12910) 2527564..2527815 - 252 WP_262532958.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA24_RS12960 (MUA24_12915) 2528117..2528218 - 102 Protein_2515 hypothetical protein -
MUA24_RS12965 (MUA24_12920) 2528225..2528824 - 600 WP_000162810.1 DsbA family protein -
MUA24_RS12970 (MUA24_12925) 2528843..2529205 - 363 WP_262532959.1 DUF4467 domain-containing protein -
MUA24_RS12975 (MUA24_12930) 2529460..2530710 + 1251 Protein_2518 FemA/FemB family glycyltransferase FmhA -
MUA24_RS12980 (MUA24_12935) 2530807..2531538 - 732 WP_262532961.1 amino acid ABC transporter ATP-binding protein -
MUA24_RS12985 (MUA24_12940) 2531535..2532251 - 717 WP_262532963.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10398.02 Da        Isoelectric Point: 10.3878

>T241342 WP_262532957.1 NZ_CP095109:c2527564-2527298 [Staphylococcus aureus]
MARLNITFSPQAFEGYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYRY

Download         Length: 267 bp

>T241342 NZ_LT992434:c2590097-2589909 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9522.70 Da        Isoelectric Point: 4.5086

>AT241342 WP_262532958.1 NZ_CP095109:c2527815-2527564 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVRSTDDKNVVIMSESDYNSMMETFYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT241342 NZ_LT992434:c2590386-2590126 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References