Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF3/-
Location 2056866..2057157 Replicon chromosome
Accession NZ_CP095109
Organism Staphylococcus aureus strain IVB6171

Toxin (Protein)


Gene name txpA Uniprot ID -
Locus tag MUA24_RS10410 Protein ID WP_078061146.1
Coordinates 2056981..2057157 (-) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 2056866..2056922 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA24_RS10385 (MUA24_10340) 2053041..2054501 - 1461 WP_262532654.1 hypothetical protein -
MUA24_RS10390 (MUA24_10345) 2055074..2055565 - 492 WP_250406032.1 staphylokinase -
MUA24_RS10395 (MUA24_10350) 2055756..2056511 - 756 WP_262532655.1 CHAP domain-containing protein -
MUA24_RS10400 (MUA24_10355) 2056523..2056777 - 255 WP_045178738.1 phage holin -
MUA24_RS10405 (MUA24_10360) 2056829..2056929 + 101 Protein_2020 hypothetical protein -
- 2056866..2056922 + 57 - - Antitoxin
MUA24_RS10410 (MUA24_10365) 2056981..2057157 - 177 WP_078061146.1 type I toxin-antitoxin system toxin PepG1 Toxin
MUA24_RS10415 (MUA24_10370) 2057358..2058137 - 780 WP_000746437.1 exotoxin -
MUA24_RS10420 (MUA24_10375) 2058592..2058960 - 369 WP_135831022.1 hypothetical protein -
MUA24_RS10425 (MUA24_10380) 2059055..2059342 - 288 WP_001040260.1 hypothetical protein -
MUA24_RS10430 (MUA24_10385) 2059389..2059541 - 153 WP_001153681.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sak / sea 2053041..2098709 45668


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6848.50 Da        Isoelectric Point: 10.6777

>T241337 WP_078061146.1 NZ_CP095109:c2057157-2056981 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSIKK

Download         Length: 177 bp

>T241337 NZ_LT992434:c991071-990895 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 57 bp

>AT241337 NZ_CP095109:2056866-2056922 [Staphylococcus aureus]
AAAAGGGCAACATGCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References