Detailed information of TA system TA241333

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1452924..1453140
• Replicon: chromosome
• Accession: NZ_CP095109
• Organism: Staphylococcus aureus strain IVB6171

Toxin (Protein)

• Gene name: SprG2
• Uniprot ID: -
• Locus tag: MUA24_RS07430
• Protein ID: WP_000255428.1
• Coordinates: 1453033..1453140 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1452924..1452978 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA24_RS07405 (MUA24_07375)	1449571..1450539	-	969	WP_262532102.1	bi-component leukocidin LukMF' subunit F'	-
MUA24_RS07410 (MUA24_07380)	1450541..1451467	-	927	WP_262532104.1	bi-component leukocidin LukMF' subunit M	-
MUA24_RS07415 (MUA24_07385)	1451814..1452569	-	756	WP_000861033.1	CHAP domain-containing protein	-
MUA24_RS07420 (MUA24_07390)	1452581..1452835	-	255	WP_000611513.1	phage holin	-
MUA24_RS07425 (MUA24_07395)	1452887..1452990	+	104	Protein_1428	hypothetical protein	-
-	1452924..1452978	+	55	-	-	Antitoxin
MUA24_RS07430 (MUA24_07400)	1453033..1453140	-	108	WP_000255428.1	putative holin-like toxin	Toxin
MUA24_RS07435 (MUA24_07405)	1453374..1453670	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
MUA24_RS07440 (MUA24_07410)	1453728..1454015	-	288	WP_001040260.1	hypothetical protein	-
MUA24_RS07445 (MUA24_07415)	1454062..1454214	-	153	WP_001153681.1	hypothetical protein	-
MUA24_RS07450 (MUA24_07420)	1454204..1457989	-	3786	WP_262532107.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / lukS-PV	1449571..1490696	41125

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (3-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3830.78 Da
• Isoelectric Point: 10.4997

>T241333 WP_000255428.1 NZ_CP095109:c1453140-1453033 [Staphylococcus aureus]
VVSVVDALNLMFSFGMFIVTLLGLVIAIVKLNHKK

Nucleotide

• Length: 108 bp

>T241333 NZ_LT991958:c241369-241082 [Enterobacter cloacae complex sp.]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Nucleotide

• Length: 55 bp

>AT241333 NZ_CP095109:1452924-1452978 [Staphylococcus aureus]
AAAAAGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Antitoxin