Detailed information of TA system TA241330

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 819932..820261
• Replicon: chromosome
• Accession: NZ_CP095109
• Organism: Staphylococcus aureus strain IVB6171

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: MUA24_RS04325
• Protein ID: WP_072357969.1
• Coordinates: 819932..820108 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	820137..820261 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA24_RS04295 (MUA24_04280)	815206..815496	+	291	WP_000179860.1	hypothetical protein	-
MUA24_RS04300 (MUA24_04285)	815512..817422	+	1911	WP_262533994.1	hypothetical protein	-
MUA24_RS04305 (MUA24_04290)	817422..818888	+	1467	WP_262533996.1	BppU family phage baseplate upper protein	-
MUA24_RS04310 (MUA24_04295)	818888..819277	+	390	WP_262533997.1	DUF2977 domain-containing protein	-
MUA24_RS04315 (MUA24_04300)	819270..819434	+	165	WP_000916021.1	XkdX family protein	-
MUA24_RS04320 (MUA24_04305)	819480..819779	+	300	WP_000466774.1	DUF2951 family protein	-
MUA24_RS04325 (MUA24_04310)	819932..820108	+	177	WP_072357969.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	820137..820261	-	125	-	-	Antitoxin
MUA24_RS04335 (MUA24_04320)	820311..820565	+	255	WP_000611512.1	phage holin	-
MUA24_RS04340 (MUA24_04325)	820577..821332	+	756	WP_262532655.1	CHAP domain-containing protein	-
MUA24_RS04345 (MUA24_04330)	821520..822011	+	492	WP_250406032.1	staphylokinase	-
MUA24_RS04350 (MUA24_04335)	822840..823076	+	237	Protein_815	hypothetical protein	-
MUA24_RS04355 (MUA24_04340)	823209..823577	+	369	WP_000765183.1	DUF423 domain-containing protein	-
MUA24_RS04360 (MUA24_04345)	823698..825179	+	1482	WP_262533998.1	APC family permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak	771734..822011	50277

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T241330 WP_072357969.1 NZ_CP095109:819932-820108 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T241330 NZ_LT991957:c4333946-4333455 [Enterobacter cloacae complex sp.]
GTGGGACGTGTAACCGCACCAGAGCCTTTAACCAGCGTCCATCAACTGGCGGAGTTCGTCAGTGGGGAAGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACGTTCGTTGTTTGTAAAACGGGCACGA
AGCAGGTAGCGGGTTTTTACTCACTGGCTACCGGCAGCGTTAACCATACGGAAGCGACCGGTAATCTACGGCGTAACATG
CCTGATCCCATTCCCGTGATTGTACTTGCCCGTCTGGCAGTCGATGTCTCATTACGTGGAAAGGGGTTGGGAGCCGATTT
GCTCCATGATGCTGTTTTACGCTGTTATCGGGTGGCAGAAAACATCGGCGTGCGGGCGATCATGGTTCACGCACTGACTG
AGGAAGCCAAGGCTTTTTATATTCACCATGGCTTCAGGGCATCGCAGACTCAGGAACGGACACTGTTTCTGAGACTTCCT
CTTACTCGATGA

Antitoxin

Nucleotide

• Length: 125 bp

>AT241330 NZ_CP095109:c820261-820137 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCGAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTTTTCATAGAAAAATTATAAAAATAACC

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin