Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3102023..3102716 Replicon chromosome
Accession NC_012967
Organism Escherichia coli B str. REL606

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag ECB_RS15295 Protein ID WP_000415584.1
Coordinates 3102420..3102716 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag ECB_RS15290 Protein ID WP_000650107.1
Coordinates 3102023..3102418 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECB_RS15280 3097887..3100145 - 2259 WP_001281877.1 DNA topoisomerase IV subunit A -
ECB_RS15285 3100283..3101890 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
ECB_RS15290 3102023..3102418 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
ECB_RS15295 3102420..3102716 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
ECB_RS15300 3102921..3103403 - 483 WP_000183505.1 transcriptional regulator -
ECB_RS15305 3103456..3103848 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
ECB_RS15310 3104000..3104659 + 660 WP_001221493.1 two-component system response regulator QseB -
ECB_RS15315 3104656..3106005 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
ECB_RS15320 3106051..3106383 - 333 WP_000917684.1 DUF2645 family protein -
ECB_RS15325 3106702..3107283 + 582 WP_000072420.1 NADPH:quinone oxidoreductase MdaB -
ECB_RS15330 3107314..3107628 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T24133 WP_000415584.1 NC_012967:c3102716-3102420 [Escherichia coli B str. REL606]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T24133 NC_012967:c3102716-3102420 [Escherichia coli B str. REL606]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT24133 WP_000650107.1 NC_012967:c3102418-3102023 [Escherichia coli B str. REL606]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT24133 NC_012967:c3102418-3102023 [Escherichia coli B str. REL606]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References