Detailed information of TA system TA241327

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 754013..754193
• Replicon: chromosome
• Accession: NZ_CP095109
• Organism: Staphylococcus aureus strain IVB6171

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: MUA24_RS03850
• Protein ID: WP_262519341.1
• Coordinates: 754098..754193 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	754013..754070 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA24_RS03820 (MUA24_03805)	750390..751580	+	1191	WP_262533884.1	restriction endonuclease subunit S	-
MUA24_RS03825 (MUA24_03810)	752217..752660	+	444	WP_262533887.1	DUF1433 domain-containing protein	-
MUA24_RS03830 (MUA24_03815)	752660..753109	+	450	WP_262533889.1	DUF1433 domain-containing protein	-
MUA24_RS03835 (MUA24_03820)	753109..753552	+	444	WP_262533892.1	DUF1433 domain-containing protein	-
MUA24_RS03840 (MUA24_03825)	753720..753896	+	177	Protein_713	transposase	-
MUA24_RS03845 (MUA24_03830)	753874..753975	-	102	WP_262520213.1	hypothetical protein	-
-	754013..754070	+	58	-	-	Antitoxin
MUA24_RS03850 (MUA24_03835)	754098..754193	-	96	WP_262519341.1	type I toxin-antitoxin system Fst family toxin	Toxin
MUA24_RS03855 (MUA24_03840)	754338..754574	+	237	WP_262533895.1	transposase	-
MUA24_RS03860 (MUA24_03845)	754616..754921	+	306	WP_262533897.1	IS3 family transposase	-
MUA24_RS03865 (MUA24_03850)	754948..755273	+	326	Protein_718	hypothetical protein	-
MUA24_RS03870 (MUA24_03855)	755284..755460	+	177	WP_000375476.1	hypothetical protein	-
MUA24_RS03875 (MUA24_03860)	755462..755647	+	186	WP_262522093.1	hypothetical protein	-
MUA24_RS03880 (MUA24_03865)	755979..756551	-	573	WP_000414222.1	hypothetical protein	-
MUA24_RS03885 (MUA24_03870)	756652..756993	-	342	WP_124375581.1	DUF3969 family protein	-
MUA24_RS03890 (MUA24_03875)	757034..757660	-	627	WP_262533903.1	hypothetical protein	-
MUA24_RS03895 (MUA24_03880)	757736..758731	-	996	WP_262533905.1	DUF4352 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlgA / lukD	732531..759426	26895
	-	flank	IS/Tn	-	-	754338..754574	236

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-118)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3582.37 Da
• Isoelectric Point: 10.4449

>T241327 WP_262519341.1 NZ_CP095109:c754193-754098 [Staphylococcus aureus]
VMLIFVHIIVPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T241327 NZ_LT991957:2173185-2173583 [Enterobacter cloacae complex sp.]
ATGCTGCATATGCTGGACACTAACATAGTAAGCCATCTGGTGAGGCAGCATCCTGAGGTTGTAAACCGATATTCGCAAAT
CACGCCTGAAAAGATGTGTATTTCAAGCGTAACGGAGGCGGAGTTGCTTTACGGCGTAGCCAAAAAGCAAAACAACAAGC
TGCACGAGACCATAATGGAATTTCTTAAGACCATAACCATCTGCGCCTGGGATAGCGAAGCCGCAGCCACCTACGGTGAA
CTGCGTGCGGCAATGGAAAAGAAAGGGAAGGTGATGGGCGATCTCGATCAGTTGATTGCCGCACACGCCATCAGCCGGGG
AACGACGATTGTCACGAACGATCGTGCCTTCGGGATGGTGCAGGATCTTACTGTTGAGGACTGGACTACCGCAGCCTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT241327 NZ_CP095109:754013-754070 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin