Detailed information of TA system TA241317

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 33063..33586
• Replicon: plasmid unnamed
• Accession: NZ_CP095101
• Organism: Staphylococcus simulans strain IVB6189

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: D3X7L5
• Locus tag: MUA87_RS12650
• Protein ID: WP_013012280.1
• Coordinates: 33063..33329 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: D3X7L6
• Locus tag: MUA87_RS12655
• Protein ID: WP_013012281.1
• Coordinates: 33329..33586 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA87_RS12620 (MUA87_12620)	28367..29041	-	675	WP_262551432.1	IS6 family transposase	-
MUA87_RS12625 (MUA87_12625)	29344..29592	-	249	WP_262551433.1	hypothetical protein	-
MUA87_RS12630 (MUA87_12630)	29606..30268	-	663	WP_262551434.1	hypothetical protein	-
MUA87_RS12635 (MUA87_12635)	30287..30907	-	621	WP_262551435.1	hypothetical protein	-
MUA87_RS12640 (MUA87_12640)	31792..32265	-	474	Protein_36	sodium:glutamate symporter	-
MUA87_RS12645 (MUA87_12645)	32319..32994	+	676	Protein_37	IS6 family transposase	-
MUA87_RS12650 (MUA87_12650)	33063..33329	-	267	WP_013012280.1	Txe/YoeB family addiction module toxin	Toxin
MUA87_RS12655 (MUA87_12655)	33329..33586	-	258	WP_013012281.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MUA87_RS12660 (MUA87_12660)	33926..34021	+	96	WP_262551436.1	type I toxin-antitoxin system Fst family toxin	-
MUA87_RS12665 (MUA87_12665)	34509..34796	+	288	Protein_41	IS6 family transposase	-
MUA87_RS12670 (MUA87_12670)	35108..35284	+	177	WP_262551438.1	hypothetical protein	-
MUA87_RS12675 (MUA87_12675)	35312..35680	+	369	WP_262551439.1	hypothetical protein	-
MUA87_RS12680 (MUA87_12680)	36367..37683	+	1317	WP_061054687.1	ISL3 family transposase	-
MUA87_RS12685 (MUA87_12685)	38018..38383	+	366	WP_262551440.1	replication/maintenance protein RepL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..55879	55879

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (9-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10601.09 Da
• Isoelectric Point: 9.9090

>T241317 WP_013012280.1 NZ_CP095101:c33329-33063 [Staphylococcus simulans]
MSYYSVLIKNSAKSDLKKINKSHLKEQFLNVVETLKINPYEPSQSFEKLQPKHLGRYSRRINHQHRIVYTVDDEKKEVYI
FSAWSHYE

Nucleotide

• Length: 267 bp

>T241317 NZ_LT991956:c42463-42047 [Enterobacter hormaechei subsp. steigerwaltii]
GTGAACAAAATTTACATGCTCGACACCTGTATCTGCTCATTCATCATGCGCGAGCAGCCGGAAGCGGTGCTGAAGCGGCT
GGAGCAGGCGGTACTGCGCAATCACCGGATCGTGGTTTCGGCCATCACCTACGCCGAGATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCGCCGCGTCACATTGAGCTGGTTGACGCGTTCTGCGCCCGTCTCGATGCCATCCAGCCCTGGGACCGCGCC
GCGGTGGACGCGACCACAGAGATCATGGTGGCGCTGCGCCTCGCCGGAACGCCGATCGGCCCGAATGACACGGCCATCGC
CGGACATGCGATAGCGGTGGGGGCCATTCTGGTGACAAACAATACCCGGGAATTTGAGCGGGTGCCGGGCCTGGTGCTGG
AAGACTGGGTTAACTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9813.90 Da
• Isoelectric Point: 4.6263

>AT241317 WP_013012281.1 NZ_CP095101:c33586-33329 [Staphylococcus simulans]
MNIKTPTNARKEFYELLKHVNVNHEPVIISGSKSENNAVIVSQKDWDSIQETLYLESVGVMDKVREREKDSSSYTNIDDL
DWSNL

Nucleotide

• Length: 258 bp

>AT241317 NZ_LT991956:c42690-42460 [Enterobacter hormaechei subsp. steigerwaltii]
ATGCGAACAGTTTCTATATTCAAAAACGGTAACAACCGCGCCATTCGCCTCCCCCGTGATCTGGATTTTGAAGGGGTGAG
TGAACTTGAAATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
AAAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCACCGACGAAGGACGGGTTGACCTGTGA

Structures

Toxin

• AlphaFold DB: D3X7L5

Antitoxin

• AlphaFold DB: D3X7L6