241274

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 739224..739917 Replicon chromosome
Accession NZ_CP095088
Organism Escherichia coli isolate w264

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag MUK78_RS03640 Protein ID WP_000415584.1
Coordinates 739224..739520 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag MUK78_RS03645 Protein ID WP_000650107.1
Coordinates 739522..739917 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUK78_RS03605 (734311) 734311..734625 - 315 WP_000958598.1 putative quinol monooxygenase -
MUK78_RS03610 (734656) 734656..735237 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
MUK78_RS03615 (735556) 735556..735889 + 334 Protein_708 DUF2645 family protein -
MUK78_RS03620 (735935) 735935..737284 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
MUK78_RS03625 (737281) 737281..737940 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
MUK78_RS03630 (738092) 738092..738484 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
MUK78_RS03635 (738537) 738537..739019 + 483 WP_000183505.1 GyrI-like domain-containing protein -
MUK78_RS03640 (739224) 739224..739520 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
MUK78_RS03645 (739522) 739522..739917 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
MUK78_RS03650 (740050) 740050..741657 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
MUK78_RS03655 (741795) 741795..744053 + 2259 WP_096037756.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T241274 WP_000415584.1 NZ_CP095088:739224-739520 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T241274 NZ_LT969520:c161704-161423 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT241274 WP_000650107.1 NZ_CP095088:739522-739917 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT241274 NZ_LT969520:c161928-161701 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References