Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 1944784..1945286 | Replicon | chromosome |
| Accession | NZ_CP095086 | ||
| Organism | Escherichia coli isolate EC5654 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | MUK77_RS09230 | Protein ID | WP_000767829.1 |
| Coordinates | 1945032..1945286 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | MUK77_RS09225 | Protein ID | WP_001259255.1 |
| Coordinates | 1944784..1945035 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUK77_RS09200 (1939962) | 1939962..1941029 | - | 1068 | WP_000080068.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| MUK77_RS09205 (1941029) | 1941029..1942099 | - | 1071 | WP_001099222.1 | histidinol-phosphate transaminase | - |
| MUK77_RS09210 (1942096) | 1942096..1943400 | - | 1305 | WP_001468360.1 | histidinol dehydrogenase | - |
| MUK77_RS09215 (1943406) | 1943406..1944305 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| MUK77_RS09220 (1944451) | 1944451..1944501 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| MUK77_RS09225 (1944784) | 1944784..1945035 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| MUK77_RS09230 (1945032) | 1945032..1945286 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| MUK77_RS09235 (1945369) | 1945369..1946193 | + | 825 | WP_000754734.1 | SDR family oxidoreductase | - |
| MUK77_RS09240 (1946239) | 1946239..1947168 | + | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
| MUK77_RS09245 (1947383) | 1947383..1947445 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| MUK77_RS09250 (1947435) | 1947435..1948793 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| MUK77_RS09255 (1948972) | 1948972..1950030 | + | 1059 | WP_000492321.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| MUK77_RS09260 (1950044) | 1950044..1950272 | + | 229 | Protein_1819 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T241239 WP_000767829.1 NZ_CP095086:1945032-1945286 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T241239 NZ_LT963402:1635685-1635867 [Pseudomonas syringae pv. avii]
GTGCAAAGCAGGCAATTGGTAAAGGAGCTTGAAGCAGATGGTTGGGTTCTTGATCGTGTCACCGGCAGTCACCATATGTT
CAAACACCCAGAAAAGTCTCAAACAGTTCCGGTGCCGCATCCCAAGAAAGACTTGCCGCTTGGAACAGTGAAGGCCATCA
GAAAGCTTGCCGGATTGGCGTAG
GTGCAAAGCAGGCAATTGGTAAAGGAGCTTGAAGCAGATGGTTGGGTTCTTGATCGTGTCACCGGCAGTCACCATATGTT
CAAACACCCAGAAAAGTCTCAAACAGTTCCGGTGCCGCATCCCAAGAAAGACTTGCCGCTTGGAACAGTGAAGGCCATCA
GAAAGCTTGCCGGATTGGCGTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT241239 WP_001259255.1 NZ_CP095086:1944784-1945035 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT241239 NZ_LT963402:1635903-1636307 [Pseudomonas syringae pv. avii]
ATGAAATATCCAATATGCATAGAGTGGGGCGATGAGACCACAGCGTTCGGCATTCAGATACCGGACATACCTGGTGCTAT
CACCGCAGGCGATACCTTTGAGGAGGCTCATGCGGCAGCCGTTGAGATCGCTCATATCATGCTGCAGGAGATTGCAGCCA
GTGGCGGGTCTATTCCGAAAGTCGGGACCGTTGCCGAGCATGCCAAAAACCCTGATTTTTCTGGAATGGGCTGGGGCATG
CTGGAAATCGATGTAACGCCTTATCTAGGCAAGACGGAAAAGGTCAACGTCACCTTGCCTGGCTTTGTGATCAGACAGAT
CGACCGCTACGTAAGGGATCACAGCATCAAAAGTCGCTCGACCTTCCTGGCTGATGCTGCGCTGGAAAAGCTCGGTCGAG
CGTGA
ATGAAATATCCAATATGCATAGAGTGGGGCGATGAGACCACAGCGTTCGGCATTCAGATACCGGACATACCTGGTGCTAT
CACCGCAGGCGATACCTTTGAGGAGGCTCATGCGGCAGCCGTTGAGATCGCTCATATCATGCTGCAGGAGATTGCAGCCA
GTGGCGGGTCTATTCCGAAAGTCGGGACCGTTGCCGAGCATGCCAAAAACCCTGATTTTTCTGGAATGGGCTGGGGCATG
CTGGAAATCGATGTAACGCCTTATCTAGGCAAGACGGAAAAGGTCAACGTCACCTTGCCTGGCTTTGTGATCAGACAGAT
CGACCGCTACGTAAGGGATCACAGCATCAAAAGTCGCTCGACCTTCCTGGCTGATGCTGCGCTGGAAAAGCTCGGTCGAG
CGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|