Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 751733..752426 Replicon chromosome
Accession NZ_CP095083
Organism Escherichia coli strain EC6868

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag MUK76_RS03650 Protein ID WP_000415585.1
Coordinates 751733..752029 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag MUK76_RS03655 Protein ID WP_000650107.1
Coordinates 752031..752426 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUK76_RS03615 (746867) 746867..747346 + 480 WP_001513449.1 Hcp family type VI secretion system effector -
MUK76_RS03620 (747349) 747349..748059 + 711 WP_001513447.1 hypothetical protein -
MUK76_RS03625 (748066) 748066..748398 + 333 WP_000914691.1 DUF2645 family protein -
MUK76_RS03630 (748444) 748444..749793 - 1350 WP_000673357.1 quorum sensing histidine kinase QseC -
MUK76_RS03635 (749790) 749790..750449 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
MUK76_RS03640 (750601) 750601..750993 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
MUK76_RS03645 (751046) 751046..751528 + 483 WP_000183505.1 GyrI-like domain-containing protein -
MUK76_RS03650 (751733) 751733..752029 + 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
MUK76_RS03655 (752031) 752031..752426 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
MUK76_RS03660 (752559) 752559..754166 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
MUK76_RS03665 (754304) 754304..756562 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 747349..762870 15521


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T241207 WP_000415585.1 NZ_CP095083:751733-752029 [Escherichia coli]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T241207 NZ_LT962934:1044688-1044933 [Brucella melitensis]
ATGAAGATCATCTGGGACGAACCGAAGCGACAGACCAACATTGCCAAGCACGGCTTGGACTTCGCTGACCTGCATTTCGA
ATTCTTCCTGTCGGCTAAGGTCTTCCCCACCAAGGCAGATCGCCTGATGGCAATCGGAGAATTCAACGGCCTGATTATCA
TCGCCGTCATTTTCAAGCCGGTTGGTTCGGAAGCCCTCTCCGTGATCTCCATGCGTTCAGCAAGCCAGAAGGAAAGGAAG
CTCTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT241207 WP_000650107.1 NZ_CP095083:752031-752426 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT241207 NZ_LT962934:1044933-1045247 [Brucella melitensis]
ATGGGTATCAAATTTTCCTCTAAGCGCCCTCTCACTCAGGAGGAAGAGGCAGAAATTCAGAAGATGATCGCAAGCGATCC
CGATGCACCGGAAGCCACCGATAAACAGCTTGCCAAGGCCAAGCCTTTCAAGGAATCCTTTCCAGATATGGCCGCCAAGA
TGGAGAAGGCCATTCGAGGCCGGCCGCGCATCGACAATCCCAAGACGCCGGTTACTATCCGGCTCGATCAGGATGTAGTT
CAACGCTTCAAGGCCACCGGCAAAGGCTGGCAGGGCCGTATGAACGATGCCCTGCGCAAAGCTGTCGGGCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZN09

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References