Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1717650..1718311 Replicon chromosome
Accession NZ_CP095045
Organism Leucobacter allii strain H21R-40

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag MUN78_RS08060 Protein ID WP_244729876.1
Coordinates 1717650..1718000 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID -
Locus tag MUN78_RS08065 Protein ID WP_244729877.1
Coordinates 1718012..1718311 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUN78_RS08030 (MUN78_08030) 1713388..1714155 - 768 WP_244729870.1 hypothetical protein -
MUN78_RS08035 (MUN78_08035) 1714152..1715072 - 921 WP_244729871.1 ATP-binding cassette domain-containing protein -
MUN78_RS08040 (MUN78_08040) 1715304..1716536 + 1233 WP_244729873.1 MFS transporter -
MUN78_RS08045 (MUN78_08045) 1716641..1716688 - 48 WP_244730039.1 zinc finger domain-containing protein -
MUN78_RS08050 (MUN78_08050) 1716722..1716967 + 246 Protein_1575 transposase -
MUN78_RS08055 (MUN78_08055) 1716879..1717412 - 534 WP_244729874.1 DUF4303 domain-containing protein -
MUN78_RS08060 (MUN78_08060) 1717650..1718000 + 351 WP_244729876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MUN78_RS08065 (MUN78_08065) 1718012..1718311 + 300 WP_244729877.1 helix-turn-helix transcriptional regulator Antitoxin
MUN78_RS08070 (MUN78_08070) 1718367..1718600 - 234 WP_244729880.1 hypothetical protein -
MUN78_RS08075 (MUN78_08075) 1718812..1718949 - 138 Protein_1580 zinc finger domain-containing protein -
MUN78_RS08080 (MUN78_08080) 1718981..1719121 + 141 Protein_1581 ArsR family transcriptional regulator -
MUN78_RS08085 (MUN78_08085) 1719121..1719630 + 510 Protein_1582 N-acetyltransferase family protein -
MUN78_RS08090 (MUN78_08090) 1719716..1719964 - 249 WP_244729882.1 hypothetical protein -
MUN78_RS08095 (MUN78_08095) 1720309..1722027 - 1719 WP_244729884.1 AIPR family protein -
MUN78_RS08100 (MUN78_08100) 1722628..1722783 + 156 WP_244729887.1 hypothetical protein -
MUN78_RS08105 (MUN78_08105) 1722791..1722994 + 204 WP_244729890.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1717650..1729551 11901


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(11-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-64)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13161.03 Da        Isoelectric Point: 8.6374

>T241190 WP_244729876.1 NZ_CP095045:1717650-1718000 [Leucobacter allii]
MWSVDIEPIARWLASLDDDSRAQVVAAIELLEDRGPQLGRPIVDTVSSSKHRNMKELRPGSSGRSELRVLFAFDPERSAI
MLIAGDKTGTWKRWYKKSIPLADDLFDDHLRSLRGK

Download         Length: 351 bp

>T241190 NZ_LT962688:c1472862-1472581 [Methylorubrum extorquens]
ATGCGGACGATTGAGCGAACCACGCAGTTCAAGCGTGACTACAAGCGGGAGATGAAGGGCAGGCACCGGGCGAGCCTTCA
AGCCGACCTGACGGCGGTGCTGACCGAGTTGGCCGCGGATCGCCCCCTCGCGGCGCGCCTGCGTGACCACGCCCTGACCG
GCAACTGGGCCGACCATCGCGACTGCCACGTGAAGCCGGATCTGGTGCTGATCTATCGGCTTGCAGGAACGGAAACGCTC
CAATTGGTGCGCCTCGGCTCGCACGCCGAACTGGGCTTCTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10985.50 Da        Isoelectric Point: 6.2322

>AT241190 WP_244729877.1 NZ_CP095045:1718012-1718311 [Leucobacter allii]
MSLKDFIAEHPVDRELVDAHKERMLAEVRAYRLRELREAAGLTQAQLAERIGVGQRQVSKIEHGDLDSAKVSTVRGYLEA
VGGSLAIEYVLGDQRVQVA

Download         Length: 300 bp

>AT241190 NZ_LT962688:c1473112-1472849 [Methylorubrum extorquens]
ATGCCGACCAAGTCGCTGATCCAGGCGCGGATCGATGCCGACACCAAGGAAGAGGCCACAGCCGTTCTCAAGGCCATGGG
GCTGACCGTCTCCGATGCGGTTCGCATGATGCTCGTGCGCGTCGCGCGAGAGAAGGCGCTTCCCTTCGAGCCTCTGGTTC
CCAACGAAACGACCATCGCAGCCATCCGCGAGGCGCGGTCCGGTAACCTTCCGGGCTTCACCAGCGTCGAGGCGCTGATG
GCCGATCTCGATGCGGACGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References