241188

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 3803712..3804379 Replicon chromosome
Accession NZ_CP095023
Organism Mycobacterium tuberculosis strain SGF0702019

Toxin (Protein)


Gene name vapC Uniprot ID O50411
Locus tag MUW68_RS17870 Protein ID WP_003417916.1
Coordinates 3803712..3804104 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8U8S7
Locus tag MUW68_RS17875 Protein ID WP_003912214.1
Coordinates 3804104..3804379 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW68_RS17850 (MUW68_17850) 3799559..3800548 - 990 WP_003417912.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
MUW68_RS17855 (MUW68_17855) 3800548..3800937 - 390 Protein_3531 polyprenyl synthetase family protein -
MUW68_RS17860 (MUW68_17860) 3800990..3802251 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
MUW68_RS17865 (MUW68_17865) 3802293..3802958 - 666 Protein_3533 polyprenyl synthetase family protein -
MUW68_RS17870 (MUW68_17870) 3803712..3804104 - 393 WP_003417916.1 type II toxin-antitoxin system VapC family toxin Toxin
MUW68_RS17875 (MUW68_17875) 3804104..3804379 - 276 WP_003912214.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUW68_RS17880 (MUW68_17880) 3804561..3805932 + 1372 Protein_3536 ISNCY family transposase -
MUW68_RS17885 (MUW68_17885) 3806122..3808299 + 2178 WP_016330440.1 PE family protein -
MUW68_RS17890 (MUW68_17890) 3808370..3809242 - 873 WP_003417929.1 3-hydroxyacyl-thioester dehydratase HtdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside IScluster/Tn - - 3800990..3805932 4942


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14316.74 Da        Isoelectric Point: 10.7249

>T241188 WP_003417916.1 NZ_CP095023:c3804104-3803712 [Mycobacterium tuberculosis]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRHPRVSSALARAEVMRALLDKGESARKAGRRALAHLDLLRVDKRVLDLAG
GLLPFELRTLDAIHLATAQRLGVDLGRLCTYDDRMRDAAKTLGMAVIAPS

Download         Length: 393 bp

>T241188 NZ_LT962481:c6008954-6008679 [Pseudomonas syringae pv. syringae]
ATGGAACTGAAGTGGACAAGCAAGGCGCTTTCTGACATTGCTAGGCTTTACGAGTTTCTGGCAGCGGTAAATCAGCCTGC
TGCTGCACGAACCGTACAGCAGCTCACGTCAGCGCCGACTACGCTGCGGACTAACCCGCGCATCGGCGAGCGCCTTGAAG
AATTTGAGCCCAGGGATGTGCGCCGGATTCAGATCGGCCATTACGAGATGCGTTACGAGATAGTGAATTCCACTGTCTAT
CTGCTGCGCCTGTGGCACTCCCGTGAAGATCGATAG

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9966.35 Da        Isoelectric Point: 4.5332

>AT241188 WP_003912214.1 NZ_CP095023:c3804379-3804104 [Mycobacterium tuberculosis]
MTSVGVRALRQRASELLRRVEAGETIEITDRGRPVALLSPLPQGGPYEQLLASGEIERATLDVVDLPEPLDLDAGVELPS
VTLARLREHER

Download         Length: 276 bp

>AT241188 NZ_LT962481:c6009226-6008954 [Pseudomonas syringae pv. syringae]
ATGGCAACAACCGCCAAAACCCGATCTGTCACGGCTCACGTTCCTGAGCAACTGGCACAAAAAGTCGATTTGATGGCAGA
GCGTCTCGAACGCTCCAAAAACTGGATCGTCAAACAGGCGCTGTCCGCTTGGATAGACCAGGAAGAGGAACGCAGTCGCC
TGACCCGCGAAGCCTTGGCTGATGTTGATGCTGGCCGCATAATCGACCACCAGGCTGTGCAGGCCTGGGCTGATAGCCTT
AGCACCGACACGGCGTTGCCGTTACCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BXS8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8U8S7

References