Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2973754..2974402 Replicon chromosome
Accession NZ_CP095023
Organism Mycobacterium tuberculosis strain SGF0702019

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag MUW68_RS14005 Protein ID WP_003899414.1
Coordinates 2973754..2974077 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag MUW68_RS14010 Protein ID WP_003899415.1
Coordinates 2974157..2974402 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW68_RS13975 (MUW68_13975) 2969077..2970075 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
MUW68_RS13980 (MUW68_13980) 2970089..2970553 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
MUW68_RS13985 (MUW68_13985) 2970541..2970792 + 252 WP_003908028.1 hypothetical protein -
MUW68_RS13990 (MUW68_13990) 2970963..2972402 - 1440 WP_003901443.1 phage major capsid protein -
MUW68_RS13995 (MUW68_13995) 2972410..2972943 - 534 WP_031666072.1 HK97 family phage prohead protease -
MUW68_RS14000 (MUW68_14000) 2973096..2973587 - 492 WP_003900541.1 phage terminase small subunit P27 family -
MUW68_RS14005 (MUW68_14005) 2973754..2974077 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
MUW68_RS14010 (MUW68_14010) 2974157..2974402 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
MUW68_RS14015 (MUW68_14015) 2974399..2975826 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
MUW68_RS14020 (MUW68_14020) 2975828..2976220 - 393 WP_003899417.1 DUF2742 domain-containing protein -
MUW68_RS14025 (MUW68_14025) 2976217..2976477 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
MUW68_RS14030 (MUW68_14030) 2976494..2976856 - 363 WP_003900543.1 hypothetical protein -
MUW68_RS14035 (MUW68_14035) 2976859..2977986 - 1128 WP_003899420.1 site-specific integrase -
MUW68_RS14040 (MUW68_14040) 2978131..2978358 - 228 WP_003899421.1 hypothetical protein -
MUW68_RS14045 (MUW68_14045) 2978355..2978744 - 390 WP_003899422.1 hypothetical protein -
MUW68_RS14050 (MUW68_14050) 2978650..2978922 + 273 WP_003900544.1 hypothetical protein -
MUW68_RS14055 (MUW68_14055) 2979021..2979254 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2969077..2977986 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-150)

Antitoxin

Vibrio phage ICP1, Orf50

(7-85)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T241177 WP_003899414.1 NZ_CP095023:c2974077-2973754 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T241177 NZ_LT960612:c619273-618776 [Vibrio tapetis subsp. tapetis]
ATGATGAACACGGTACTTCTAGAAAAAGCAAAACATGATAGAAACCGGTTCAACTGTGGCATTGAAGCTCTTAATAACTA
TCTGAAGATTATGGCGAGTCAACAAGCAAAGAAAGACAACACCAGAACTTTCGTTTTAGAAGATGATAATGATAACTCGC
ATATCATTGGTTTTTACACGCTGACAATGACACCAATTGATTTGAAAGCTTTACCCGACAAACTACAGAAAAAACACCAA
TCATCCACCTCTGGTGGTTTAATAGCCCGCTTAGCTGTCGATGACCGCTACAAAGGAAAAGGATTTGGCGAATGGTTGCT
GATTGATGCACTCAGAAAGCTACTAGCTGCCAGTGATAGTGTCGCATTCCCTGTAGTTATTGTTGACGCCAAAGACGGCG
CGAAACACTTCTACGAGCGCTATGGATTCCAAACGTTTCAAGACTCAGAAAACAAACTCTTTATTACCATTTCTGACGTA
AGAGCGAACTTAGGCTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT241177 WP_003899415.1 NZ_CP095023:c2974402-2974157 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT241177 NZ_LT960612:c619542-619270 [Vibrio tapetis subsp. tapetis]
ATGGCTAATACTTTACCTCGCATCACTGCTAGAGTTGATGTCGATACACAAAACCTACTGACAAAAGCAGCTGCAATTGC
TGGTATGTCTAGTATTAACTCATTTGTTCTAAGTGCTGCTATCGAAAAAGCCAAACAAGTAATTGAACGAGAGCAAGCAC
TTAAACTTAGCCAAGCTGATGCCATGTTACTTATGGACGCTTTAGACCGTCCTTCAACAATCAACTCAAAATTGAAAGCT
GCTTCTGACCGCTACGATAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References